Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors (Q57462255)

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2 April 2020

title

Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors (English)

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2 April 2020

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2 April 2020

Alison M Nagle

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2 April 2020

Nilgun Tasdemir

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2 April 2020

Julie A Scott

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2 April 2020

Kara Burlbaugh

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2 April 2020

Justin Kehm

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2 April 2020

Tiffany A Katz

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2 April 2020

David N Boone

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2 April 2020

Britta M Jacobsen

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2 April 2020

Jennifer M Atkinson

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2 April 2020

Steffi Oesterreich

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2 April 2020

Adrian V Lee

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2 April 2020

language of work or name

English

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publication date

25 June 2018

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2 April 2020

published in

Clinical Cancer Research

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volume

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issue

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2 April 2020

page(s)

5165-5177

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

2 April 2020

cites work

1 reference

12 December 2020

Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells

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12 December 2020

Crosstalk between the insulin-like growth factors and estrogens in breast cancer.

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12 December 2020

Role of the IGF-I receptor in the regulation of cell-cell adhesion: implications in cancer development and progression

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12 December 2020

The IGF‐1 receptor in cancer biology

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12 December 2020

A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.

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12 December 2020

E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases.

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12 December 2020

Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin

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12 December 2020

Insulin-like growth factors and neoplasia

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12 December 2020

Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

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12 December 2020

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

1 reference

12 December 2020

Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

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12 December 2020

Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt.

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12 December 2020

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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12 December 2020

Distinct clinical and prognostic features of infiltrating lobular carcinoma of the breast: combined results of 15 International Breast Cancer Study Group clinical trials

1 reference

12 December 2020

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

1 reference

12 December 2020

Lobular and ductal carcinomas of the breast have distinct genomic and expression profiles

1 reference

12 December 2020

Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

1 reference

12 December 2020

BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells

1 reference

12 December 2020

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

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12 December 2020

Clinical and biological significance of E-cadherin protein expression in invasive lobular carcinoma of the breast

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12 December 2020

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy

1 reference

12 December 2020

The IGF pathway regulates ERα through a S6K1-dependent mechanism in breast cancer cells

1 reference

12 December 2020

Hallmarks of Cancer: The Next Generation

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12 December 2020

PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

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12 December 2020

Cancer invasion and the microenvironment: plasticity and reciprocity

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12 December 2020

Cellular distribution of the IGF-1R in corneal epithelial cells

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12 December 2020

Targeting the insulin-like growth factor receptor: developing biomarkers from gene expression profiling

1 reference

12 December 2020

Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors.

1 reference

12 December 2020

Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features

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12 December 2020

Occurrence and significance of epithelial-mesenchymal transition in breast cancer

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12 December 2020

Ex vivo culture of human prostate tissue and drug development

1 reference

12 December 2020

Insulin-like growth factor - oestradiol crosstalk and mammary gland tumourigenesis

1 reference

12 December 2020

Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin

1 reference

12 December 2020

Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer.

1 reference

12 December 2020

Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response

1 reference

12 December 2020

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

1 reference

12 December 2020

Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses

1 reference

12 December 2020

Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation

1 reference

12 December 2020

Targeting the IGF-1R: The Tale of the Tortoise and the Hare

1 reference

12 December 2020

IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance

1 reference

12 December 2020

Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial

1 reference

12 December 2020

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

1 reference

12 December 2020

Tumor microenvironment in invasive lobular carcinoma: possible therapeutic targets.

1 reference

12 December 2020

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

1 reference

12 December 2020

Comparison of clinical outcomes between luminal invasive ductal carcinoma and luminal invasive lobular carcinoma

1 reference

12 December 2020

Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways.

1 reference

12 December 2020

Differences between invasive lobular and invasive ductal carcinoma of the breast: results and therapeutic implications

1 reference

12 December 2020

Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells

1 reference

12 December 2020

Cadherin tales: Regulation of cadherin function by endocytic membrane trafficking

1 reference

12 December 2020

Active Estrogen Receptor-alpha Signaling in Ovarian Cancer Models and Clinical Specimens

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12 December 2020

PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression.

1 reference

12 December 2020

Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin

1 reference

12 December 2020

SynergyFinder: a web application for analyzing drug combination dose-response matrix data

1 reference

12 December 2020

Invasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinoma

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12 December 2020

Revisiting the IGF-1R as a breast cancer target.

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12 December 2020

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer.

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12 December 2020

10.1158/1078-0432.CCR-18-0279

Identifiers

DOI

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2 April 2020

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2 April 2020

PubMed publication ID

29941485

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