PINK1: one protein, multiple neuroprotective functions (Q57243906)

The PINK1 phenotype can be indistinguishable from idiopathic Parkinson disease

21 January 2018

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Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes

21 January 2018

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T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease

21 January 2018

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PINK1 mutations and parkinsonism

21 January 2018

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Mutation analysis of the PINK1 gene in 391 patients with Parkinson disease

21 January 2018

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Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism

21 January 2018

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Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease

21 January 2018

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PINK1 mutations are associated with sporadic early-onset parkinsonism

21 January 2018

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PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism

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Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations

21 January 2018

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Phenotypic characterisation of autosomal recessive PARK6-linked parkinsonism in three unrelated Italian families

21 January 2018

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Late onset sporadic Parkinson's disease caused by PINK1 mutations: clinical and functional study

21 January 2018

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PINK1 heterozygous rare variants: prevalence, significance and phenotypic spectrum

21 January 2018

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PINK1 mutation heterozygosity and the risk of Parkinson's disease

21 January 2018

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BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

21 January 2018

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Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

21 January 2018

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Distribution of PINK1 and LRRK2 in rat and mouse brain

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Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease

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PINK1 protein in normal human brain and Parkinson's disease

21 January 2018

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PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains

21 January 2018

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Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

21 January 2018

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The kinase domain of mitochondrial PINK1 faces the cytoplasm

21 January 2018

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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

21 January 2018

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C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

21 January 2018

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

21 January 2018

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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

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Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo

21 January 2018

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Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

21 January 2018

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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

21 January 2018

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Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1.

21 January 2018

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Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.

21 January 2018

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Characterization of PINK1 processing, stability, and subcellular localization

21 January 2018

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

21 January 2018

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Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

21 January 2018

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Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

21 January 2018

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Lewy-body formation is an aggresome-related process: a hypothesis

21 January 2018

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FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation

21 January 2018

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The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function

21 January 2018

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Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease

21 January 2018

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Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.

21 January 2018

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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

21 January 2018

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Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.

21 January 2018

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Mitochondrial association of alpha-synuclein causes oxidative stress

21 January 2018

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Convergent roles of alpha-synuclein, DA metabolism, and the ubiquitin-proteasome system in nigrostriatal toxicity

21 January 2018

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PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease

21 January 2018

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Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux

21 January 2018

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Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease

21 January 2018

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Parkin counteracts symptoms in a Drosophila model of Parkinson's disease

21 January 2018

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Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

21 January 2018

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Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

21 January 2018

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Parkinson patient fibroblasts show increased alpha-synuclein expression

21 January 2018

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

21 January 2018

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

21 January 2018

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Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture

21 January 2018

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Calcium and neurodegeneration

21 January 2018

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Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels

21 January 2018

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Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 January 2018

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PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

21 January 2018

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Functions and dysfunctions of mitochondrial dynamics

21 January 2018

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Mitochondrial fragmentation in neurodegeneration

21 January 2018

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

21 January 2018

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21 January 2018

Parkin blushed by PINK1.

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

21 January 2018

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Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

21 January 2018

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The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

21 January 2018

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Autophagy in the Pathogenesis of Disease

21 January 2018

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

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Autophagy in neurodegeneration and development

21 January 2018

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Selective degradation of mitochondria by mitophagy

21 January 2018

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Parkin-induced mitophagy in the pathogenesis of Parkinson disease

21 January 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

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Molecular interaction between parkin and PINK1 in mammalian neuronal cells

21 January 2018

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Parkin stabilizes PINK1 through direct interaction

21 January 2018

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High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

21 January 2018

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The biochemistry of Parkinson's disease

21 January 2018

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Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

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Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

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Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys

21 January 2018

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Lack of nigrostriatal pathology in a rat model of proteasome inhibition

21 January 2018

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Proteasome inhibition and Parkinson's disease modeling

21 January 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

21 January 2018

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Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

21 January 2018

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Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study

21 January 2018

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Dopaminergic function in a family with the PARK6 form of autosomal recessive Parkinson's syndrome

21 January 2018

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Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

21 January 2018

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

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Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

21 January 2018

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Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin.

21 January 2018

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Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.

21 January 2018

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The PINK1/Parkin pathway regulates mitochondrial morphology

21 January 2018

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Loss of PINK1 function affects development and results in neurodegeneration in zebrafish

21 January 2018

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Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish

21 January 2018

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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

21 January 2018

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Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

21 January 2018

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Juvenile-Onset Parkinsonism as a Result of the First Mutation in the Adenosine Triphosphate Orientation Domain of PINK1

21 January 2018

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Parkinson's Disease-associated α-Synuclein Is a Calmodulin Substrate

21 January 2018

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A heterozygous effect for PINK1 mutations in Parkinson's disease?

21 January 2018

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