A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF (Q57184035)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Georg Schett

1 reference

16 January 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

author name string

Vagelis Rinotas

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Eleni Makrinou

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Jochen Zwerina

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

publication date

7 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

page(s)

784-798

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

Reaching a genetic and molecular understanding of skeletal development

16 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

RANK is essential for osteoclast and lymph node development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Central control of fever and female body temperature by RANKL/RANK

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Regulation of cancer cell migration and bone metastasis by RANKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

RANK(L) as a key target for controlling bone loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Denosumab for prevention of fractures in postmenopausal women with osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Denosumab in men receiving androgen-deprivation therapy for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Mutations within the TNF-like core domain of RANKL impair osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

The affinity of human RANK binding to its ligand RANKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Small-molecule inhibition of TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Structural and functional insights of RANKL-RANK interaction and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Mixed metastatic lung cancer lesions in bone are inhibited by noggin overexpression and Rank:Fc administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Heterotrimers formed by tumor necrosis factors of different species or muteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Genome-wide ENU mutagenesis to reveal immune regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

R/qtl: QTL mapping in experimental crosses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

CHARMM: the biomolecular simulation program

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

Effects of ENU dosage on mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR510

21 January 2018

Identifiers

DOI

10.1093/HMG/DDR510

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json