Sodium channels as molecular targets for antiepileptic drugs (Q57042785)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

review article

1 reference

title

Sodium channels as molecular targets for antiepileptic drugs (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

D S Ragsdale

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11 November 2019

M Avoli

series ordinal

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11 November 2019

language of work or name

English

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publication date

1 March 1998

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11 November 2019

volume

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11 November 2019

issue

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11 November 2019

page(s)

16-28

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Contribution of the S4 segment to gating charge in the Shaker K+ channel.

11 November 2019

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On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain

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Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

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Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones.

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An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

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Persistent sodium current in mammalian central neurons

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Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy

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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

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Ultra-deep blockade of Na+ channels by a quaternary ammonium ion: catalysis by a transition-intermediate state?

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Tissue-specific expression of the RI and RII sodium channel subtypes

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Molecular model of the action potential sodium channel

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Calcium channel characteristics conferred on the sodium channel by single mutations

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7 January 2021

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

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Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

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The components of membrane conductance in the giant axon of Loligo

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The dual effect of membrane potential on sodium conductance in the giant axon of Loligo

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A quantitative description of membrane current and its application to conduction and excitation in nerve

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7 January 2021

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

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7 January 2021

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

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7 January 2021

Auxiliary subunits of voltage-gated ion channels

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7 January 2021

Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

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7 January 2021

Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line

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7 January 2021

Na+ channel subunits and Ig domains

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7 January 2021

Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes

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7 January 2021

Structure, function and expression of voltage-dependent sodium channels

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7 January 2021

Primary structure of rat brain sodium channel III deduced from the cDNA sequence

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7 January 2021

Role of inactivation in local anesthetic action

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7 January 2021

Inactivation of cloned Na channels expressed in Xenopus oocytes

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7 January 2021

Na+ channels must deactivate to recover from inactivation

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7 January 2021

Carbamazepine inhibition of neuronal Na+ currents: quantitative distinction from phenytoin and possible therapeutic implications

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7 January 2021

Transmembrane movement of the shaker K+ channel S4.

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7 January 2021

Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex

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7 January 2021

Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

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7 January 2021

Pore loops: an emerging theme in ion channel structure

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7 January 2021

Three brain sodium channel α-subunit genes are clustered on the proximal segment of mouse chromosome 2

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7 January 2021

Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24

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7 January 2021

Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31

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7 January 2021

Specific and potent interactions of carbamazepine with brain adenosine receptors

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7 January 2021

A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation

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7 January 2021

Inhibition by topiramate of seizures in spontaneously epileptic rats and DBA/2 mice

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7 January 2021

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

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7 January 2021

Existence of distinct sodium channel messenger RNAs in rat brain

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7 January 2021

Expression of functional sodium channels from cloned cDNA.

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7 January 2021

The epileptogenic effects of folate derivatives in the rat.

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7 January 2021

Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker

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7 January 2021

Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.

1 reference

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7 January 2021

Effect of Carbamazepine on the In Vitro Uptake and Release of Norepinephrine in Adrenergic Nerves of Rabbit Aorta and in Whole Brain Synaptosomes

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7 January 2021

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

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7 January 2021

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

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7 January 2021

Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy

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7 January 2021

Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs

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7 January 2021

Structural basis of ion channel permeation and selectivity

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7 January 2021

A novel, abundant sodium channel expressed in neurons and glia

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7 January 2021

Voltage Dependent Charge Movement in Skeletal Muscle: a Possible Step in Excitation–Contraction Coupling

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7 January 2021

Phenytoin and carbamazepine: potential- and frequency-dependent block of Na currents in mammalian myelinated nerve fibers

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7 January 2021

Late Sodium Channel Openings Underlying Epileptiform Activity Are Preferentially Diminished by the Anticonvulsant Phenytoin

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7 January 2021

Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel

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7 January 2021

Topiramate: preclinical evaluation of structurally novel anticonvulsant.

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7 January 2021

Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 1. Neurochemical Studies

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7 January 2021

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

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7 January 2021

Structural parts involved in activation and inactivation of the sodium channel

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7 January 2021

Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker

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7 January 2021

Double-blind, placebo-controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy

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7 January 2021

Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome

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7 January 2021

μl Na+ channels expressed transiently in human embryonic kidney cells: Biochemical and biophysical properties

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7 January 2021

Identification of an intracellular peptide segment involved in sodium channel inactivation

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7 January 2021

Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells

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7 January 2021

Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons.

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7 January 2021

Topiramate: a potent anticonvulsant in the amygdala-kindled rat

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7 January 2021

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

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7 January 2021

Efficient expression of rat brain type IIA Na+ channel α subunits in a somatic cell line

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7 January 2021

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

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7 January 2021

Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

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7 January 2021

Molecular basis of charge movement in voltage-gated sodium channels

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7 January 2021

Lamotrigine: a review of antiepileptic efficacy

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7 January 2021

Amine blockers of the cytoplasmic mouth of sodium channels: a small structural change can abolish voltage dependence

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7 January 2021

A single linkage group comprising 11 polymorphic DNA markers on rat Chromosome 3

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7 January 2021

Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture.

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7 January 2021

Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells

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7 January 2021

Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture

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7 January 2021

10.1016/S0165-0173(97)00054-4

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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