IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells (Q57038233)

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scientific article published on 03 October 2018

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English	IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells	scientific article published on 03 October 2018

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Europe PubMed Central

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6200646

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26 April 2020

title

IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells (English)

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6200646

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26 April 2020

author

Jonathan H Davis

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12

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6200646

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26 April 2020

Xi Chen

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5

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Xi Chen

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6200646

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26 April 2020

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Natasha C Ward

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1

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6200646

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26 April 2020

Aixin Yu

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2

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26 April 2020

Alejandro Moro

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3

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26 April 2020

Yuguang Ban

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4

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26 April 2020

Sunnie Hsiung

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6

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26 April 2020

James Keegan

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7

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26 April 2020

Jaren M Arbanas

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8

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26 April 2020

Martine Loubeau

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9

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26 April 2020

Anil Thankappan

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10

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26 April 2020

Aaron P Yamniuk

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11

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6200646

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26 April 2020

Mary Struthers

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13

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6200646

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26 April 2020

Thomas R Malek

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14

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language of work or name

English

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publication date

3 October 2018

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26 April 2020

published in

Journal of Immunology

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6200646

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26 April 2020

volume

201

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issue

9

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6200646

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26 April 2020

page(s)

2579-2592

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Cytoscape

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cites work

Long term culture of tumour-specific cytotoxic T cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of recombinant interleukin 2 in humans

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin 2 receptor: relationship to the interleukin 2-binding site

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The murine interleukin 2 receptor. IV. Biochemical characterization

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The murine interleukin 2 receptor. Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune responses in interleukin-2-deficient mice

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alpha chain of the IL-2 receptor determines the species specificity of high-affinity IL-2 binding

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2: clinical applications

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of albumin fusion on the biodistribution of interleukin-2

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A function for interleukin 2 in Foxp3-expressing regulatory T cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonredundant roles for Stat5a/b in directly regulating Foxp3

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of interleukin-2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enrichment map: a network-based method for gene-set enrichment visualization and interpretation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 and regulatory T cells in graft-versus-host disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT5 is a potent negative regulator of TFH cell differentiation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAR: ultrafast universal RNA-seq aligner

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human IL-2 mutein with higher antitumor efficacy than wild type IL-2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for the IL-2 receptor in Treg cell function

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30282751

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.4049/JIMMUNOL.1800907

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stated in

Europe PubMed Central

PMC publication ID

6200646

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30282751%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 April 2020

PMC publication ID

6200646

1 reference

stated in

Europe PubMed Central

PMC publication ID

6200646

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30282751%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 April 2020

PubMed publication ID

30282751

1 reference

stated in

Europe PubMed Central

PMC publication ID

6200646

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30282751%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 April 2020

 

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