Rational evolutionary design: The theory of in vitro protein evolution (Q56690317)

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Fitness spectrum among random mutants on Mt. Fuji-type fitness landscape

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Adaptive Walks by the Fittest among Finite Random Mutants on a Mt. Fuji-type Fitness Landscape

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Population dynamics in a spin-glass model of chemical evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Quantification of tertiary structural conservation despite primary sequence drift in the globin fold

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Neutral networks in protein space: a computational study based on knowledge-based potentials of mean force

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The enzymic nature of antibody catalysis: development of multistep kinetic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Error Thresholds on Correlated Fitness Landscapes

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

How are model protein structures distributed in sequence space?

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Point mutations as an optimal search process in biological evolution

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Stability of Designed Proteins against Mutations

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The relation between the divergence of sequence and structure in proteins

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Evolution of a protein fold in vitro

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

DNA shuffling of a family of genes from diverse species accelerates directed evolution

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

De Novo Protein Design: Fully Automated Sequence Selection

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Antibody affinity maturation using bacterial surface display.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Context dependence of phenotype prediction and diversity in combinatorial mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Searching sequence space to engineer proteins: exponential ensemble mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Random-Energy Model: Limit of a Family of Disordered Models

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Random-energy model: An exactly solvable model of disordered systems

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Non-equilibrium thermodynamics of molecular evolution

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Principles of protein folding--a perspective from simple exact models.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Selection of new biologically active molecules from random nucleotide sequences.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Conformational analysis of the backbone-dependent rotamer preferences of protein sidechains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Selforganization of matter and the evolution of biological macromolecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The Molecular Quasi-Species

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https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Molecular quasi-species

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Evolution in a rugged fitness landscape

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Physical aspects of evolutionary optimization and adaptation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Shaping space: the possible and the attainable in RNA genotype-phenotype mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

A computer model of evolutionary optimization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Continuity in evolution: on the nature of transitions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

RNA folding and combinatory landscapes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Genetic algorithms: principles of natural selection applied to computation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The Energy Landscapes and Motions of Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Correlation length, isotropy and meta-stable states

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Strategies for epitope analysis using peptide synthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Molecular Evolution Over the Mutational Landscape

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Protein plasticity to the extreme: changing the topology of a 4-alpha-helical bundle with a single amino acid substitution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The foldability landscape of model proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Evolution of model proteins on a foldability landscape

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Adaptive mutagenesis: a process that generates almost exclusively beneficial mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Error Detecting and Error Correcting Codes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Engineering surface loops of proteins--a preferred strategy for obtaining new enzyme function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The hydrophobic core of Escherichia coli thioredoxin shows a high tolerance to nonconservative single amino acid substitutions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Exploring phenotype space through neutral evolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

SELEXION. Systematic evolution of ligands by exponential enrichment with integrated optimization by non-linear analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an alpha-helical protein with over 50% sequence identity to an all-beta protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Protein design by binary patterning of polar and nonpolar amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Towards a general theory of adaptive walks on rugged landscapes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Applied molecular evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Search strategies for applied molecular evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The NK model of rugged fitness landscapes and its application to maturation of the immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The neutral theory of molecular evolution: A review of recent evidence

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Non-Darwinian Evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Optimization by Simulated Annealing

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Enzyme catalysis: not different, just better

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Mean-field minimization methods for biological macromolecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Directed evolution of enzyme catalysts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Predicting protein mutant energetics by self-consistent ensemble optimization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Stochastic modeling and optimization of phage display

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Adaptive walks with noisy fitness measurements

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Emergence of Preferred Structures in a Simple Model of Protein Folding

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Long-range, small magnitude nonadditivity of mutational effects in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Enzymatic Catalysis and Transition-State Theory

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

A mathematical model for biopanning (affinity selection) using peptide libraries on filamentous phage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

1 reference

7 January 2021

Nonadditivity of mutational effects on the properties of catalase I and its application to efficient directed evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Natural Selection and the Concept of a Protein Space

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

When learning guides evolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Equation of State Calculations by Fast Computing Machines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Exploring nonnatural evolutionary pathways by saturation mutagenesis: rapid improvement of protein function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences 1 1Edited by J. Wells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Error thresholds of replication in finite populations mutation frequencies and the onset of Muller's ratchet

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Slightly Deleterious Mutant Substitutions in Evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Role of random genetic drift in the evolution of interactive systems

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Structural Diversity in a Family of Homologous Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Theoretical studies of clonal selection: Minimal antibody repertoire size and reliability of self-non-self discrimination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Selective chemical catalysis by an antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Analysis of genetic algorithms using statistical mechanics.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Functionally acceptable substitutions in two alpha-helical regions of lambda repressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Generic properties of combinatory maps: Neutral networks of RNA secondary structures

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

In vitro selection of nucleic acids and proteins: What are we learning?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Landscapes: complex optimization problems and biopolymer structures

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Proteins with selected sequences fold into unique native conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Random-priming in vitro recombination: An effective tool for directed evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Engineering new functions and altering existing functions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Solvable Model of a Spin-Glass

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Creating novel enzymes by applied molecular evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Landscapes and their correlation functions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Anisotropy in fitness landscapes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Rapid evolution of a protein in vitro by DNA shuffling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

The Shannon information entropy of protein sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Genetic algorithms and evolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Modeling DNA shuffling.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Tolerance of different proteins for amino acid diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Folding and misfolding of designed proteinlike chains with mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Viral RNA and evolved mutational robustness

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

QUANTITATIVE VARIATION IN FINITE PARTHENOGENETIC POPULATIONS: WHAT STOPS MULLER'S RATCHET IN THE ABSENCE OF RECOMBINATION?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Statistics of kinetic pathways on biased rough energy landscapes with applications to protein folding.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Optimization by stimulating molecular evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Local properties of Kauffman’s N - k model: A tunably rugged energy landscape

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Additivity of mutational effects in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Identification of residues involved in a conformational change accompanying substitutions for glutamate-43 in staphylococcal nuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Adaptive walks on time-dependent fitness landscapes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Combinatorial protein design: strategies for screening protein libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Optimization of DNA shuffling for high fidelity recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Directed evolution converts subtilisin E into a functional equivalent of thermitase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

Molecular evolution by staggered extension process (StEP) in vitro recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2801%2955003-2

1 reference

7 January 2021