Ras activation in astrocytomas and neurofibromas. (Q55477300)

12 July 2018

review article

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title

Ras activation in astrocytomas and neurofibromas. (English)

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12 July 2018

author name string

Guha A

series ordinal

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12 July 2018

publication date

1 November 1998

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12 July 2018

Canadian Journal of Neurological Sciences

published in

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12 July 2018

volume

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12 July 2018

issue

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12 July 2018

page(s)

267-281

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12 July 2018

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites

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Clonal expansion of p53 mutant cells is associated with brain tumour progression

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Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells

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Identification and characterization of the neurofibromatosis type 1 protein product

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

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Analysis of Epidermal Growth Factor Receptor Gene Amplification and Alteration in Stereotactic Biopsies of Brain Tumors

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Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

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Ras C-terminal processing enzymes--new drug targets?

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Proliferation of human malignant astrocytomas is dependent on Ras activation

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Mutation and cancer: statistical study of retinoblastoma

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All ras proteins are polyisoprenylated but only some are palmitoylated

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Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

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The implications of angiogenesis for the biology and therapy of cancer metastasis

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Somatic mutations in the neurofibromatosis 1 gene in human tumors

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

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7 January 2021

The neurofibromatosis type 1 gene and its protein product, neurofibromin.

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7 January 2021

Identification of the neurofibromatosis type 1 gene product

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7 January 2021

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

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7 January 2021

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

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7 January 2021

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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7 January 2021

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

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7 January 2021

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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7 January 2021

Molecular and biological properties of the vascular endothelial growth factor family of proteins

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Src homology region 2 domains direct protein-protein interactions in signal transduction

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7 January 2021

Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome

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7 January 2021

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

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7 January 2021

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

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7 January 2021

NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation

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7 January 2021

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells

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7 January 2021

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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7 January 2021

Protein modules and signalling networks

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7 January 2021

PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

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7 January 2021

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cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product

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The Son of sevenless Gene Product: a Putative Activator of Ras

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7 January 2021

Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells

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7 January 2021

Screening of neurofibromatosis type 1 gene: identification of a large deletion and of an intronic variant.

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7 January 2021

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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7 January 2021

Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway.

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7 January 2021

Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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7 January 2021

National survey of patterns of care for brain-tumor patients

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7 January 2021

Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms

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7 January 2021

Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins.

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7 January 2021

SH2 domains recognize specific phosphopeptide sequences

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7 January 2021

Grading of astrocytomas. A simple and reproducible method.

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7 January 2021

Meningiomas: role of vascular endothelial growth factor/vascular permeability factor in angiogenesis and peritumoral edema

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7 January 2021

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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7 January 2021

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

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7 January 2021

Dominant-negative mutants of a platelet-derived growth factor gene

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7 January 2021

Protein kinase C isoforms in human glioblastoma cells

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7 January 2021

The PTB domain: a new protein module implicated in signal transduction

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7 January 2021

Ras signaling and NF1.

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7 January 2021

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Molecular genetic characterization of CNS tumor oncogenesis

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Genomic organization of the neurofibromatosis 1 gene (NF1).

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

ras GTPase activating protein: signal transmitter and signal terminator

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: the key to angiogenesis?

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Oncogenes and signal transduction

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Vascular endothelial growth factor is a secreted angiogenic mitogen

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF.

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Analysis of mutations at the neurofibromatosis 1 (NF1) locus

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells

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7 January 2021

Acute presentation of a neurogenic sarcoma in a patient with neurofibromatosis type 1: a pathological and molecular explanation. Case report

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7 January 2021

The neurofibromatosis type 1 gene encodes a protein related to GAP

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP

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7 January 2021

Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Differential regulation of rasGAP and neurofibromatosis gene product activities

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

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7 January 2021

Regulatory mechanisms for ras proteins

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7 January 2021

Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells

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7 January 2021

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Angiogenic and invasive properties of neurofibroma Schwann cells

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity

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https://api.crossref.org/works/10.1017%2FS0317167100034272

7 January 2021

What Is the Evidence That Tumors Are Angiogenesis Dependent?

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7 January 2021

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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7 January 2021

Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains

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7 January 2021

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

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12 July 2018