Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect. (Q55333258)

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English	Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect.	scientific article

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26 March 2020

Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect (English)

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26 March 2020

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26 March 2020

Katsuzumi Okumura

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Katsuzumi Okumura

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26 March 2020

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Masumi Okamura

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26 March 2020

Yasutaka Yamanaka

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26 March 2020

Maki Shigemoto

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26 March 2020

Yuya Kitadani

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26 March 2020

Yuhko Kobayashi

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26 March 2020

Taiho Kambe

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26 March 2020

Masaya Nagao

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26 March 2020

Issei Kobayashi

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26 March 2020

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10 May 2018

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26 March 2020

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26 March 2020

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26 March 2020

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26 March 2020

e0197165

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26 March 2020

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Creative Commons Attribution 4.0 International

10 May 2018

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11 June 2022

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RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies

1 reference

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3 July 2018

RNA Export through the NPC in Eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Cytoplasmic hGle1A regulates stress granules by modulation of translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis

1 reference

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3 July 2018

DNA damage and its links to neurodegeneration

1 reference

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3 July 2018

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

1 reference

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3 July 2018

Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.

1 reference

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3 July 2018

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

1 reference

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3 July 2018

Altered ribostasis: RNA-protein granules in degenerative disorders

1 reference

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3 July 2018

A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Gle1 is a multifunctional DEAD-box protein regulator that modulates Ded1 in translation initiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

SnapShot: Inositol Phosphates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

miRNA malfunction causes spinal motor neuron disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Control of mRNA export and translation termination by inositol hexakisphosphate requires specific interaction with Gle1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

The DEAD-box RNA helicase Dbp5 functions in translation termination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

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A syndrome of multiple congenital contractures: neuropathological analysis on five fetal cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

3 July 2018

Gle1 regulates RNA binding of the DEAD-box helicase Ded1 in its complex role in translation initiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

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An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

12 August 2018

Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

12 August 2018

Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

12 August 2018

The DEAD-box protein Dbp5 controls mRNA export by triggering specific RNA:protein remodeling events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

12 August 2018

Inositol polyphosphates regulate zebrafish left-right asymmetry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

12 August 2018

Polo-like kinase 1 (PLK1) expression is associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945018

12 August 2018

Gle1 does double duty

1 reference

https://pubmed.ncbi.nlm.nih.gov/29746542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptors and innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29746542

12 December 2020

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10.1371/JOURNAL.PONE.0197165

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26 March 2020

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26 March 2020

PubMed publication ID

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26 March 2020

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