FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation. (Q54597920)

1 June 2018

title

FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation. (English)

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1 June 2018

author name string

Vu HA

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1 June 2018

Xinh PT

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1 June 2018

Masuda M

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1 June 2018

Motoji T

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1 June 2018

Toyoda A

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1 June 2018

Sakaki Y

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1 June 2018

Tokunaga K

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1 June 2018

Sato Y

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1 June 2018

publication date

8 June 2006

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1 June 2018

published in

Leukemia

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1 June 2018

volume

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1 June 2018

issue

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1 June 2018

page(s)

1414-1421

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1 June 2018

Tyrosine kinase fusion genes in chronic myeloproliferative diseases.

cites work

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

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Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter

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Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

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Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

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A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma

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A t(6;12)(q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line.

21 January 2018

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Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)

21 January 2018

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Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis.

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AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

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Signal transduction of oncogenic Flt3.

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Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1.

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Establishment and characterization of A novel Philadelphia-chromosome positive chronic myeloid leukemia cell line, TCC-S, expressing P210 and P190 BCR/ABL transcripts but missing normal ABL gene

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Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581

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A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase

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Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.LEU.2404266

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1 June 2018

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1 June 2018