Angiopoietin-2 TIEs Up Macrophages in Tumor Angiogenesis (Q54589611)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21576085%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Angiopoietin-2 TIEs up macrophages in tumor angiogenesis (English)

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1 February 2020

Angiopoietin-2 TIEs Up Macrophages in Tumor Angiogenesis (English)

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Crossref

DOI

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

2 December 2024

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1 February 2020

Michele De Palma

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1 February 2020

language of work or name

English

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publication date

16 May 2011

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full work available at URL

1 February 2020

https://aacrjournals.org/clincancerres/article-pdf/17/16/5226/1997463/5226.pdf

file format

Portable Document Format

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Crossref

DOI

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

2 December 2024

published in

Clinical Cancer Research

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1 February 2020

volume

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issue

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1 February 2020

page(s)

5226-5232

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Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

1 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

How do angiopoietins Tie in with vascular endothelial growth factors?

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Expression of Tie-2 by human monocytes and their responses to angiopoietin-2

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Regulation of tie2 expression by angiopoietin--potential feedback system

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Targeting the ANGPT-TIE2 pathway in malignancy

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Pericytes limit tumor cell metastasis

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors

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1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors

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1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors

2 December 2024

1 reference

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0171

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells.

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1 reference

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Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment

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1 reference

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Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells

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Active Immunotherapy Induces Antibody Responses That Target Tumor Angiogenesis

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2 December 2024

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21576085%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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