LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice (Q43916892)

28 November 2017

title

LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice (English)

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28 November 2017

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28 November 2017

Vassilis I Zannis

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28 November 2017

publication date

7 December 2005

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Journal of Lipid Research

28 November 2017

published in

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28 November 2017

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28 November 2017

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28 November 2017

page(s)

521-529

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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

28 November 2017

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The amino-terminal 1-185 domain of apoE promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoE-deficient mice.

21 January 2018

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Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion

21 January 2018

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Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding.

21 January 2018

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21 January 2018

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21 January 2018

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Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects

21 January 2018

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21 January 2018

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The apolipoprotein E2 (Arg145Cys) mutation causes autosomal dominant type III hyperlipoproteinemia with incomplete penetrance

21 January 2018

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Abnormal in vivo metabolism of apolipoprotein E4 in humans

21 January 2018

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Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol

21 January 2018

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10.1194/JLR.M500322-JLR200

21 January 2018

Identifiers

DOI

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28 November 2017

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