Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration. (Q43907188)

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scientific article published on 17 July 2017

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English	Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration.	scientific article published on 17 July 2017

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2 April 2020

Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration (English)

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2 April 2020

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2 April 2020

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Yiwei Li

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Irfana Muqbil

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Amro Aboukameel

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William Senapedis

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Erkan Baloglu

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Yosef Landesman

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Sharon Shacham

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Michael G Kauffman

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Philip A Philip

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Ramzi M Mohammad

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2 April 2020

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2 April 2020

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2 April 2020

82144-82155

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2 April 2020

Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone

1 reference

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25 May 2018

MiR-145 functions as a tumor suppressor via regulating angiopoietin-2 in pancreatic cancer cells

1 reference

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25 May 2018

miR-145 suppresses breast cancer cell migration by targeting FSCN-1 and inhibiting epithelial-mesenchymal transition

1 reference

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AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner

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Paradoxical role of SOX2 in gastric cancer

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Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro

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Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer.

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25 May 2018

Cancer statistics, 2016

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Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma

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25 May 2018

KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models.

1 reference

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25 May 2018

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

1 reference

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25 May 2018

Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.

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25 May 2018

MYC, Metabolism, and Cancer

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25 May 2018

MicroRNA-145 suppresses cell migration and invasion by targeting paxillin in human colorectal cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5669877

25 May 2018

Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression

1 reference

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25 May 2018

Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer

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25 May 2018

The role of p21-activated kinases in pancreatic cancer

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25 May 2018

Exportin-5 mediates nuclear export of SRP RNA in vertebrates

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25 May 2018

Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing

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25 May 2018

Cancer statistics, 2015

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5669877

25 May 2018

miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma

1 reference

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25 May 2018

Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells

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25 May 2018

KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5669877

25 May 2018

KPT-330 has antitumour activity against non-small cell lung cancer

1 reference

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25 May 2018

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer

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Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

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25 May 2018

MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer

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25 May 2018

XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer

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25 May 2018

Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

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The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf

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MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1.

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MicroRNA-145 function as a cell growth repressor by directly targeting c-Myc in human ovarian cancer

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Nuclear export mediated regulation of microRNAs: potential target for drug intervention

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MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

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Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice

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Restitution of Tumor Suppressor MicroRNA-145 Using Magnetic Nanoformulation for Pancreatic Cancer Therapy

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1 reference

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1 reference

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MicroRNAs as oncogenes and tumor suppressors

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNAs--the micro steering wheel of tumour metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.19285

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Europe PubMed Central

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2 April 2020

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2 April 2020

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2 April 2020

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