CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity (Q43559545)

24 November 2017

title

CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity (English)

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24 November 2017

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24 November 2017

K Kitagawa

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24 November 2017

M Kitagawa

series ordinal

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24 November 2017

T Kawamoto

series ordinal

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24 November 2017

language of work or name

English

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publication date

16 February 2001

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Journal of Biological Chemistry

24 November 2017

published in

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24 November 2017

volume

276

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24 November 2017

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24 November 2017

page(s)

17830-17835

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A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

24 November 2017

cites work

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Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

21 January 2018

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The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP

21 January 2018

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Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans

21 January 2018

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The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

21 January 2018

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Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

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CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians

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Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus

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Expression of mammalian cytochrome P450 using baculovirus

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High-resolution crystal structure of cytochrome P450cam

21 January 2018

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Expression of CYP2A genes in human liver and extrahepatic tissues.

21 January 2018

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Mutagenesis at a highly conserved phenylalanine in cytochrome P450 2E1 affects heme incorporation and catalytic activity.

21 January 2018

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Genetic polymorphism of CYP2A6 in the German population

21 January 2018

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A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

21 January 2018

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21 January 2018

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Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

21 January 2018

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Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

21 January 2018

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Molecular modelling of members of the P4502A subfamily: application to studies of enzyme specificity

21 January 2018

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Structural alignments of P450s and extrapolations to the unknown

21 January 2018

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The common I172N mutation causes conformational change of cytochrome P450c21 revealed by systematic mutation, kinetic, and structural studies

21 January 2018

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Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population

21 January 2018

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Metabolism of [3-14C]coumarin to polar and covalently bound products by hepatic microsomes from the rat, Syrian hamster, gerbil and humans

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M009432200

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24 November 2017

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