Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions (Q43424784)

23 November 2017

title

Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions (English)

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23 November 2017

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Binfeng Xia

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23 November 2017

Tycho Heimbach

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23 November 2017

Tsu-han Lin

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23 November 2017

Handan He

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23 November 2017

Yanfeng Wang

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23 November 2017

Eugene Tan

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23 November 2017

publication date

11 April 2012

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Cancer Chemotherapy and Pharmacology

23 November 2017

published in

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23 November 2017

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23 November 2017

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23 November 2017

page(s)

1567-1582

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The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

23 November 2017

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Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo

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Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo

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Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma.

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Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

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21 January 2018

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Structural Basis of the Activity of the Microtubule-Stabilizing Agent Epothilone A Studied by NMR Spectroscopy in Solution

21 January 2018

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10.1007/S00280-012-1863-5

21 January 2018

Identifiers

DOI

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Dimensions Publication ID

23 November 2017

1032065524

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