Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines (Q42913207)

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scientific article published on September 8, 2010

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English	Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines	scientific article published on September 8, 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines (English)

1 reference

10.1523/JNEUROSCI.2357-10.2010

https://api.crossref.org/works/10.1523/JNEUROSCI.2357-10.2010

9 July 2024

phosphorylation

0 references

Eckhard Mandelkow

3

object named as

Eckhard Mandelkow

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Eva-Maria Mandelkow

4

object named as

Eva-Maria Mandelkow

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

author name string

Hans Zempel

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633549&resulttype=core&format=json

15 May 2020

Edda Thies

2

1 reference

Europe PubMed Central

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15 May 2020

language of work or name

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publication date

1 September 2010

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Europe PubMed Central

PubMed publication ID

11 November 2017

8 September 2010

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National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20826658

9 July 2024

full work available at URL

https://www.jneurosci.org/content/jneuro/30/36/11938.full.pdf

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20826658

9 July 2024

http://www.jneurosci.org/cgi/content/abstract/30/36/11938

online access status

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20826658

9 July 2024

https://europepmc.org/articles/PMC6633549

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Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20826658

9 July 2024

https://europepmc.org/articles/PMC6633549?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20826658

9 July 2024

https://doi.org/10.1523/jneurosci.2357-10.2010

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20826658

9 July 2024

https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.2357-10.2010

1 reference

10.1523/JNEUROSCI.2357-10.2010

https://api.crossref.org/works/10.1523/JNEUROSCI.2357-10.2010

9 July 2024

Journal of Neuroscience

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633549&resulttype=core&format=json

15 May 2020

30

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Europe PubMed Central

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15 May 2020

36

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633549&resulttype=core&format=json

15 May 2020

11938-11950

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633549&resulttype=core&format=json

15 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6633549/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Beta-amyloid precursor protein is detectable on monocytes and is increased in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau is essential to beta -amyloid-induced neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer disease: mechanistic understanding predicts novel therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A high-affinity protein stain for western blots, tissue prints, and electrophoretic gels

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

{beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau, tangles, and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian SAD kinases are required for neuronal polarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The axonal transport of mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau phosphorylation and proteolysis: insights and perspectives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In search of the molecular basis of memory loss in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology and pathophysiology of purinergic neurotransmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Swimming against the tide: mobility of the microtubule-associated protein tau in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models of Alzheimer's disease and frontotemporal dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural classification of toxic amyloid oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein assembly and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beyond polymer polarity: how the cytoskeleton builds a polarized cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau pathophysiology in neurodegeneration: a tangled issue

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule assembly, organization and dynamics in axons and dendrites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmission and spreading of tauopathy in transgenic mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Introducing intermediate filaments: from discovery to disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic targeting by A beta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: synaptic dysfunction and Abeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axon degeneration: Mechanisms and implications of a distinct program from cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium lability of cytoplasmic microtubules and its modulation by microtubule-associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble amyloid beta-protein in the cerebrospinal fluid from patients with Alzheimer's disease, vascular dementia and controls.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20826658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2357-10.2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633549&resulttype=core&format=json

15 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633549&resulttype=core&format=json

15 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633549&resulttype=core&format=json

15 May 2020

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