Identification of a novel PDX-1 binding site in the human insulin gene enhancer (Q42830601)

8 November 2017

title

Identification of a novel PDX-1 binding site in the human insulin gene enhancer (English)

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8 November 2017

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John Le Lay

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8 November 2017

Taka-Aki Matsuoka

series ordinal

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8 November 2017

Eva Henderson

series ordinal

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8 November 2017

Roland Stein

series ordinal

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8 November 2017

language of work or name

English

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publication date

16 March 2004

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Journal of Biological Chemistry

8 November 2017

published in

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8 November 2017

volume

279

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8 November 2017

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8 November 2017

page(s)

22228-22235

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Effect of 5'-flanking sequence deletions on expression of the human insulin gene in transgenic mice.

8 November 2017

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Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes

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MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

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Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells

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Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

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Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor

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Programming of the pancreas

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Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

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Insulin-promoter-factor 1 is required for pancreas development in mice

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Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

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Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance

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BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells

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The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells

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Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.

21 January 2018

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Insulin upstream factor 1 and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoter

21 January 2018

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Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells

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Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1

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Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription

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Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

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Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2.

21 January 2018

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Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element

21 January 2018

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Differential regulation of the human insulin gene transcription by GG1 and GG2 elements with GG- and C1-binding factors

21 January 2018

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GGAAAT motifs play a major role in transcriptional activity of the human insulin gene in a pancreatic islet beta-cell line MIN6.

21 January 2018

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The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene

21 January 2018

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Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression

21 January 2018

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The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.

21 January 2018

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21 January 2018

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Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex

21 January 2018

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Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6

21 January 2018

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Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins

21 January 2018

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Oligonucleotide trapping method for purification of transcription factors

21 January 2018

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Global haplotype diversity in the human insulin gene region

21 January 2018

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Regulation of insulin gene transcription

21 January 2018

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Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

21 January 2018

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Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

21 January 2018

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RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon

21 January 2018

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Regulation of insulin gene transcription

21 January 2018

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The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer

21 January 2018

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The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

21 January 2018

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Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1

21 January 2018

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Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

21 January 2018

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Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M312673200

1 reference

8 November 2017

1 reference