Pregabalin is a potent and selective ligand for α2δ-1 and α2δ-2 calcium channel subunits (Q42732657)

6 November 2017

title

Pregabalin is a potent and selective ligand for α(2)δ-1 and α(2)δ-2 calcium channel subunits (English)

1 reference

6 November 2017

Pregabalin is a potent and selective ligand for α2δ-1 and α2δ-2 calcium channel subunits (English)

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

4 December 2024

Zheng Li

1 reference

6 November 2017

Mark Weber

1 reference

6 November 2017

Julie Piechan

1 reference

6 November 2017

Faith Prior

1 reference

6 November 2017

Feng Bian

1 reference

6 November 2017

Mei Cui

1 reference

6 November 2017

Diane Hoffman

1 reference

6 November 2017

Sean Donevan

1 reference

6 November 2017

Charles P. Taylor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21651903

4 December 2024

language of work or name

English

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publication date

1 June 2011

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6 November 2017

30 September 2011

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21651903

full work available at URL

4 December 2024

https://api.elsevier.com/content/article/PII:S0014299911006376?httpAccept=text/xml

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

https://api.elsevier.com/content/article/PII:S0014299911006376?httpAccept=text/plain

4 December 2024

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

European Journal of Pharmacology

4 December 2024

published in

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6 November 2017

volume

667

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6 November 2017

issue

1-3

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6 November 2017

page(s)

80-90

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The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin

6 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein.

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Pregabalin modulation of neurotransmitter release is mediated by change in intrinsic activation/inactivation properties of ca(v)2.1 calcium channels

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Multiple actions of arylalkylamine arthropod toxins on the N-methyl-D-aspartate receptor

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Gabapentin is not a GABAB receptor agonist

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

(L)-Phenylglycine, but not necessarily other alpha2delta subunit voltage-gated calcium channel ligands, attenuates neuropathic pain in rats

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Gabapentin promotes inhibition by enhancing hyperpolarization-activated cation currents and spontaneous firing in hippocampal CA1 interneurons

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Mechanisms of analgesia by gabapentin and pregabalin--calcium channel alpha2-delta [Cavalpha2-delta] ligands

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Immunostaining of rat brain, spinal cord, sensory neurons and skeletal muscle for calcium channel alpha2-delta (alpha2-delta) type 1 protein

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Acute modulation of calcium currents and synaptic transmission by gabapentinoids.

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding

4 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2011.05.054

4 December 2024

Identifiers

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6 November 2017

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