Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial (Q42650874)

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English	Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

phase I clinical trial

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Parkinson's disease

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based on heuristic

inferred from title

Charles Warren Olanow

10

object named as

C Warren Olanow

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Europe PubMed Central

PubMed publication ID

4 November 2017

author name string

William J Marks

1

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4 November 2017

Jill L Ostrem

2

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Europe PubMed Central

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4 November 2017

Leonard Verhagen

3

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Europe PubMed Central

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4 November 2017

Philip A Starr

4

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Europe PubMed Central

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4 November 2017

Paul S Larson

5

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PubMed publication ID

4 November 2017

Roy Ae Bakay

6

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4 November 2017

Robin Taylor

7

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4 November 2017

Deborah A Cahn-Weiner

8

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4 November 2017

A Jon Stoessl

9

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4 November 2017

Raymond T Bartus

11

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4 November 2017

publication date

2 April 2008

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4 November 2017

Lancet Neurology

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4 November 2017

7

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4 November 2017

5

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Europe PubMed Central

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4 November 2017

400-408

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Europe PubMed Central

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4 November 2017

Neuropathology of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2808%2970065-6

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based on heuristic

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The scientific basis for the current treatment of Parkinson's disease

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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

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Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease.

1 reference

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7 January 2021

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Functional recovery in parkinsonian monkeys treated with GDNF

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Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

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Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor

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Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

1 reference

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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

1 reference

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Crossroads in GDNF therapy for Parkinson's disease

1 reference

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Convective delivery of glial cell line-derived neurotrophic factor in the human putamen

1 reference

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Point source concentration of GDNF may explain failure of phase II clinical trial

1 reference

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based on heuristic

inferred from DOI database lookup

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

1 reference

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based on heuristic

inferred from DOI database lookup

Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys

1 reference

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based on heuristic

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Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons

1 reference

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based on heuristic

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Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons

1 reference

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AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease

1 reference

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based on heuristic

inferred from DOI database lookup

Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease

1 reference

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7 January 2021

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Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys

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What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study

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Implantation of deep brain stimulators into the subthalamic nucleus: technical approach and magnetic resonance imaging-verified lead locations

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The development and validation of a short measure of functioning and well being for individuals with Parkinson's disease.

1 reference

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A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease

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Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease

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The role of radiotracer imaging in Parkinson disease

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Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

1 reference

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Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.

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Identifiers

10.1016/S1474-4422(08)70065-6

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

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