The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials (Q42571291)

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scientific article published on 8 November 2010

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English	The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials	scientific article published on 8 November 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials (English)

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

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1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Amy E Mercer

1

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Ian M Copple

2

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

James L Maggs

3

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Paul M O'Neill

4

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

B Kevin Park

5

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Europe PubMed Central

PMC publication ID

2 November 2017

language of work or name

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publication date

8 November 2010

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Europe PubMed Central

PMC publication ID

2 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

2 November 2017

286

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

2

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

987-996

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Artesunate derived from traditional Chinese medicine induces DNA damage and repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Resistance of mtDNA-depleted cells to apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Artemisinin-based combination treatment of falciparum malaria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

New developments in synthetic peroxidic drugs as artemisinin mimics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Are currently deployed artemisinins neurotoxic?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

The antimalarial drug artemisinin alkylates heme in infected mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Mitochondrial metabolism of reactive oxygen species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Artemisinin induces apoptosis in human cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

A medicinal chemistry perspective on artemisinin and related endoperoxides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Artemisinins target the SERCA of Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

The iron metabolism of neoplastic cells: alterations that facilitate proliferation?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Intracellular ATP, a switch in the decision between apoptosis and necrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Safety assessment of peroxide antimalarials: clinical and chemical perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Mitochondria and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Abnormal DNA patterns in animal mitochondria: ethidium bromide-induced breakdown of closed circular DNA and conditions leading to oligomer accumulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Qinghaosu-induced changes in the morphology of Plasmodium inui.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Sequential induction of heme pathway enzymes during erythroid differentiation of mouse Friend leukemia virus-infected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

The oxidation of tiron by superoxide anion. Kinetics of the reaction in aqueous solution and in chloroplasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

28 May 2018

Artemisinin resistance on the Thai-Cambodian border

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

ATP depletion alters the mode of cell death induced by benzyl isothiocyanate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

EVALUATION OF THE TRYPAN BLUE TECHNIQUE FOR DETERMINATION OF CELL VIABILITY

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Alkylation of heme by the antimalarial drug artemisinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

The anti-malarial artesunate is also active against cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3020783

16 August 2018

Artemisinin resistance in Plasmodium falciparum malaria

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https://api.crossref.org/works/10.1074%2FJBC.M110.144188

21 January 2018

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

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https://api.crossref.org/works/10.1074%2FJBC.M110.144188

21 January 2018

Morphologic effects of artemisinin in Plasmodium falciparum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21059641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Artemisinin enhances heme-catalysed oxidation of lipid membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21059641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome c-mediated apoptosis in cells lacking mitochondrial DNA. Signaling pathway involving release and caspase 3 activation is conserved

1 reference

https://pubmed.ncbi.nlm.nih.gov/21059641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of cellular proliferation by modulation of oxidative phosphorylation in human and rodent fast-growing tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21059641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.144188

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

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