G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice. (Q42056965)

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scientific article published on 12 March 2013

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English	G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice.	scientific article published on 12 March 2013

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scholarly article

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25 February 2020

G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice (English)

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25 February 2020

G protein-coupled receptor

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Nandakumar Packiriswamy

1

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25 February 2020

Narayanan Parameswaran

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25 February 2020

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Taehyung Lee

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25 February 2020

Pongali B Raghavendra

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25 February 2020

Haritha Durairaj

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25 February 2020

Hongbing Wang

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25 February 2020

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12 March 2013

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25 February 2020

Journal of Innate Immunity

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25 February 2020

5

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25 February 2020

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25 February 2020

401-413

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25 February 2020

G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition

1 reference

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5 June 2018

Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice.

1 reference

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5 June 2018

Role of myeloid-specific G-protein coupled receptor kinase-2 in sepsis

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5 June 2018

G-protein coupled receptor kinase 5 regulates prostate tumor growth

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5 June 2018

G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.

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5 June 2018

Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo

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5 June 2018

GRK5 promotes F-actin bundling and targets bundles to membrane structures to control neuronal morphogenesis

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5 June 2018

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs

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5 June 2018

G Protein-Coupled Receptor Kinase 5 Phosphorylation of Hip Regulates Internalization of the Chemokine Receptor CXCR4

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Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival.

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5 June 2018

GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.

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5 June 2018

G‐protein coupled receptor kinase 5 mediates lipopolysaccharide‐induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice

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5 June 2018

The pathogenesis of sepsis.

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5 June 2018

The role of interferon-γ in the pathogenesis of acute intra-abdominal sepsis

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5 June 2018

Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins

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5 June 2018

Regulation of Lrp6 phosphorylation

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5 June 2018

G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis

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5 June 2018

IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.

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5 June 2018

G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.

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5 June 2018

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling

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5 June 2018

The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia

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5 June 2018

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

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5 June 2018

Administration of exogenous fractalkine, a CX3C chemokine, is capable of modulating inflammatory response in cecal ligation and puncture-induced sepsis

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5 June 2018

Physiological roles of G protein-coupled receptor kinases and arrestins

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5 June 2018

Evaluation of endotoxin models for the study of sepsis

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5 June 2018

Role of C5a-C5aR interaction in sepsis

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5 June 2018

Prevention of lymphocyte cell death in sepsis improves survival in mice

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5

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Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes

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Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling

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17 August 2018

Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.

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Enhancement of NF-kappaB activation in lymphocytes prevents T cell apoptosis and improves survival in murine sepsis.

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Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation.

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Combination of imipenem and TAK-242, a Toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis

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https://pubmed.ncbi.nlm.nih.gov/23485819

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23485819

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inpatient care for septicemia or sepsis: a challenge for patients and hospitals

1 reference

https://pubmed.ncbi.nlm.nih.gov/23485819

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis detection by annexin V binding: a novel method for the quantitation of cell-mediated cytotoxicity

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective macrophage suppression during sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23485819

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cecal ligation and puncture

1 reference

https://pubmed.ncbi.nlm.nih.gov/23485819

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23485819

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23485819

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1159/000347002

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25 February 2020

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25 February 2020

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25 February 2020

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