Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450 (Q41673463)

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scientific article published on January 1, 1997

Language	Label	Description	Also known as
English	Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450	scientific article published on January 1, 1997

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 October 2017

1 reference

Europe PubMed Central

Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450 (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9416773

30 November 2024

site-directed mutagenesis

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9416773

30 November 2024

sequence homology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9416773

30 November 2024

author name string

G. D. Szklarz

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9416773

30 November 2024

J. R. Halpert

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9416773

30 November 2024

language of work or name

0 references

publication date

1 January 1997

1 reference

Europe PubMed Central

PubMed publication ID

6 October 2017

1997

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9416773

30 November 2024

number of pages

14

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based on heuristic

inferred from page(s)

full work available at URL

https://api.elsevier.com/content/article/PII:S0024320597007170?httpAccept=text/xml

1 reference

10.1016/S0024-3205(97)00717-0

https://api.crossref.org/works/10.1016/S0024-3205(97)00717-0

30 November 2024

https://api.elsevier.com/content/article/PII:S0024320597007170?httpAccept=text/plain

1 reference

10.1016/S0024-3205(97)00717-0

https://api.crossref.org/works/10.1016/S0024-3205(97)00717-0

30 November 2024

1 reference

Europe PubMed Central

PubMed publication ID

6 October 2017

61

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Europe PubMed Central

PubMed publication ID

6 October 2017

26

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Europe PubMed Central

PubMed publication ID

6 October 2017

2507-2520

1 reference

Europe PubMed Central

PubMed publication ID

6 October 2017

describes a project that uses

site-directed mutagenesis

1 reference

based on heuristic

inferred from title

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

1 reference

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The human hepatic cytochromes P450 involved in drug metabolism

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High-resolution crystal structure of cytochrome P450cam

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

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Structure of cytochrome P450eryF involved in erythromycin biosynthesis

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Site-Directed Mutagenesis as a Tool for Molecular Modeling of Cytochrome P450 2B1

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Application of 3-Dimensional Homology Modeling of Cytochrome P450 2B1 for Interpretation of Site-Directed Mutagenesis Results

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Using molecular modeling and molecular dynamics simulation to predict P450 oxidation products

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A 175-psec molecular dynamics simulation of camphor-bound cytochrome P-450cam

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Predicting the product specificity and coupling of cytochrome P450cam

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Molecular modeling of the 3-D structure of cytochrome P-450scc

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A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

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Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues

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Molecular modelling of members of the P4502A subfamily: application to studies of enzyme specificity

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7 January 2021

Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

1 reference

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7 January 2021

Structure and function of cytochromes P450: a comparative analysis of three crystal structures

1 reference

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7 January 2021

P450s: structural similarities and functional differences.

1 reference

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7 January 2021

A three-dimensional model of aromatase cytochrome P450.

1 reference

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7 January 2021

A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108

1 reference

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7 January 2021

Molecular modeling of cytochrome P450 3A4

1 reference

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7 January 2021

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

1 reference

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7 January 2021

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

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7 January 2021

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

1 reference

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7 January 2021

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

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Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies

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Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase

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Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites

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Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1

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Identification of Three Key Residues in Substrate Recognition Site 5 of Human Cytochrome P450 3A4 by Cassette and Site-Directed Mutagenesis

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Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.

1 reference

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Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues

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Controlling the regiospecificity and coupling of cytochrome P450cam: T185F mutant increases coupling and abolishes 3-hydroxynorcamphor product

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Binding free energy calculations for P450cam-substrate complexes

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British Journal of Pharmacology

37

112

244P

author name string

ELLIS

publication date

1994

1 reference

10.1016/S0024-3205(97)00717-0

https://api.crossref.org/works/10.1016/S0024-3205(97)00717-0

30 November 2024

Molecular Pharmacology

44

46

338

author name string

HASLER

publication date

1994

1 reference

10.1016/S0024-3205(97)00717-0

https://api.crossref.org/works/10.1016/S0024-3205(97)00717-0

30 November 2024

Identifiers

10.1016/S0024-3205(97)00717-0

1 reference

Europe PubMed Central

PubMed publication ID

6 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 October 2017

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