Clinical pharmacokinetics of newer antiepileptic drugs. Lamotrigine, vigabatrin, gabapentin and oxcarbazepine (Q41101288)

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scientific article published on June 1996

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Language	Label	Description	Also known as
English	Clinical pharmacokinetics of newer antiepileptic drugs. Lamotrigine, vigabatrin, gabapentin and oxcarbazepine	scientific article published on June 1996

Statements

instance of

scholarly article

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

review article

1 reference

stated in

Europe PubMed Central

title

Clinical pharmacokinetics of newer antiepileptic drugs. Lamotrigine, vigabatrin, gabapentin and oxcarbazepine (English)

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stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

main subject

gabapentin

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lamotrigine

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based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

author name string

R D Elwes

series ordinal

1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

C D Binnie

series ordinal

2

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

publication date

1 June 1996

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

published in

Clinical Pharmacokinetics

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stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

volume

30

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stated in

Europe PubMed Central

PubMed publication ID

8792055

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26 September 2017

issue

6

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stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

page(s)

403-415

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Europe PubMed Central

PubMed publication ID

8792055

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26 September 2017

cites work

A profile of vigabatrin

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multicentre study of vigabatrin for drug-resistant epilepsy

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-vinyl GABA (vigabatrin): relationship between dosage, plasma concentrations, platelet GABA-transaminase inhibition, and seizure reduction in epileptic children

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First dose and steady-state pharmacokinetics of oxcarbazepine and its 10-hydroxy metabolite

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical development outlook of oxcarbazepine

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of vigabatrin: implications of creatinine clearance

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prognosis for seizure control in newly diagnosed epilepsy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Possible interaction between oxcarbazepine and an oral contraceptive

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term study of gamma-vinyl GABA in the treatment of epilepsy

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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inferred from PubMed ID database lookup

Gabapentin as add-on therapy in refractory partial epilepsy: a double-blind, placebo-controlled, parallel-group study. The US Gabapentin Study Group No. 5

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Oxcarbazepine does not affect the anticoagulant activity of warfarin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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inferred from PubMed ID database lookup

Vigabatrin does not affect the intestinal absorption of phenytoin in rat duodeno-jejunal loops in situ

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Cerebrospinal fluid GABA and seizure control with vigabatrin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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inferred from PubMed ID database lookup

Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Seven day administration of lamotrigine in epilepsy: placebo-controlled add-on trial

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selected CSF biochemistry and gabapentin concentrations in the CSF and plasma in patients with partial seizures after a single oral dose of gabapentin

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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inferred from PubMed ID database lookup

Clinical pharmacology and pharmacokinetics of oxcarbazepine

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Determination of GABA and vigabatrin in human plasma by a rapid and simple HPLC method: correlation between clinical response to vigabatrin and increase in plasma GABA

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of the individual enantiomers of vigabatrin (gamma-vinyl GABA) in epileptic children

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of vigabatrin on epilepsy in mentally retarded patients: a 7-month follow-up study.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-blind study of Gabapentin in the treatment of partial seizures

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

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Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

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Use of thermospray liquid chromatography-mass spectrometry to aid in the identification of urinary metabolites of a novel antiepileptic drug, Lamotrigine

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Acute effects of lamotrigine (BW430C) in persons with epilepsy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Clinical efficacy and safety of gabapentin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Oxcarbazepine does not interact with cimetidine in healthy volunteers

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Vigabatrin in complex partial seizures: a long-term study

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-vinyl-GABA: a single-blind trial in patients with epilepsy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Emerging perspectives on the mechanism of action of gabapentin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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inferred from PubMed ID database lookup

Oxcarbazepine: mechanisms of action

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

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Survey of 260 epileptic patients treated with oxcarbazepine (Trileptal) on a named-patient basis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the enzyme, GABA-aminotransferase in human platelets by vigabatrin, a potential antiepileptic drug

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-blind, placebo controlled, crossover study of lamotrigine in treatment resistant partial seizures

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between vigabatrin and phenytoin

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

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Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

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Vigabatrin in the treatment of childhood epilepsies: a single-blind placebo-controlled study

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Therapeutic experiences with 947 epileptic out-patients in oxcarbazepine treatment

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Comparison of oxcarbazepine and carbamazepine: a double-blind study

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

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Effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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The influence of age on the pharmacokinetics of the antiepileptic agent oxcarbazepine

1 reference

stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

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Psychophysiological and psychometric studies after manipulating the GABA system by vigabatrin, a GABA-transaminase inhibitor

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Gabapentin as an antiepileptic drug in man

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

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Lack of enzyme induction with oxcarbazepine (600 mg daily) in healthy subjects

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

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A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

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Clinical experience with oxcarbazepine

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lamotrigine-induced carbamazepine toxicity: an interaction with carbamazepine-10,11 -epoxide

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of the antiepileptic oxcarbazepine and its metabolites in healthy volunteers

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro N-glucuronidation of a novel antiepileptic drug, lamotrigine, by human liver microsomes

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats

1 reference

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https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Dose dependent enzyme induction by oxcarbazepine?

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

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Double-blind dose reduction study of vigabatrin in complex partial epilepsy.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-blind, placebo-controlled study of vigabatrin (gamma-vinyl GABA) in drug-resistant epilepsy.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxcarbazepine (GP 47.680): a possible alternative to carbamazepine?

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

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Clinical pharmacokinetics of gabapentin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of food on the disposition of the antiepileptic oxcarbazepine and its major metabolites in healthy volunteers

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

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Kinetics of the enantiomers of vigabatrin after an oral dose of the racemate or the active S-enantiomer

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vigabatrin-induced decrease in serum phenytoin concentration does not involve a change in phenytoin bioavailability.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of food on the absorption of vigabatrin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gabapentin in partial epilepsy. UK Gabapentin Study Group

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of vigabatrin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

retrieved

12 December 2020

based on heuristic

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Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8792055

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12 December 2020

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Identifiers

DOI

10.2165/00003088-199630060-00001

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

Dimensions Publication ID

1051328824

0 references

PubMed publication ID

8792055

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8792055

retrieved

26 September 2017

 

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