Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis (Q40990999)

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scientific article published on September 2016

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English	Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis	scientific article published on September 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

25 September 2017

Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis (English)

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

hypertriglyceridemia

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based on heuristic

inferred from title

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based on heuristic

inferred from title

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based on heuristic

inferred from title

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27582413%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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Hai Wang

1

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13 June 2020

Miaoyun Zhao

2

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13 June 2020

Neetu Sud

3

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13 June 2020

Patricia Christian

4

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13 June 2020

Jing Shen

5

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13 June 2020

Yongyan Song

6

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13 June 2020

Anjeza Pashaj

7

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13 June 2020

Timothy Carr

9

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13 June 2020

Qiaozhu Su

10

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13 June 2020

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publication date

1 September 2016

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25 September 2017

Scientific Reports

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13 June 2020

6

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13 June 2020

32246

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13 June 2020

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Creative Commons Attribution 4.0 International

1 September 2016

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April 2022 Public Data File from Crossref

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Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid

1 reference

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25 September 2017

Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis.

1 reference

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25 September 2017

Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH

1 reference

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25 September 2017

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

1 reference

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25 September 2017

The role of CREB-H transcription factor in triglyceride metabolism

1 reference

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25 September 2017

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

1 reference

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25 September 2017

Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome

1 reference

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25 September 2017

Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin

1 reference

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25 September 2017

Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs

1 reference

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25 September 2017

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.

1 reference

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25 September 2017

Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance

1 reference

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25 September 2017

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

1 reference

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25 September 2017

Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles

1 reference

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25 September 2017

The glucagon receptor is required for the adaptive metabolic response to fasting

1 reference

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25 September 2017

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

1 reference

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25 September 2017

Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007496

25 September 2017

Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis.

1 reference

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25 September 2017

Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007496

25 September 2017

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

1 reference

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25 September 2017

Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation

1 reference

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25 September 2017

Hyperphosphorylation regulates the activity of SREBP1 during mitosis

1 reference

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25 September 2017

Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise

1 reference

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25 September 2017

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

1 reference

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25 September 2017

Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats

1 reference

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25 September 2017

CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma

1 reference

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Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

1 reference

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

1 reference

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25 September 2017

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007496

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

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Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

1 reference

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1 reference

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17 June 2018

The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism

1 reference

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17 June 2018

A phosphorylation cascade controls the degradation of active SREBP1.

1 reference

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19 August 2018

Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver

1 reference

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A common genetic variant is associated with adult and childhood obesity

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19 August 2018

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

1 reference

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Evidence of hepatic glucagon resistance associated with hepatic steatosis: reversal effect of training

1 reference

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Effects of Exogenous Glucagon on Lipids in Lipoproteins and Liver of Lactating Dairy Cows

1 reference

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Prevention of fatty liver in transition dairy cows by subcutaneous injections of glucagon

1 reference

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12 December 2020

based on heuristic

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10.1038/SREP32246

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27582413%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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Europe PubMed Central

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13 June 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27582413%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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