3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation (Q40945823)

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scientific article published on July 1999

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English	3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation	scientific article published on July 1999

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 September 2017

3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation (English)

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Europe PubMed Central

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25 September 2017

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S Y Jeong

1

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Europe PubMed Central

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25 September 2017

S G Ahn

2

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25 September 2017

J H Lee

3

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25 September 2017

H S Kim

4

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Europe PubMed Central

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25 September 2017

J W Kim

5

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25 September 2017

H Rhim

6

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25 September 2017

S W Jeong

7

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25 September 2017

I K Kim

8

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25 September 2017

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publication date

1 July 1999

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25 September 2017

Journal of Biological Chemistry

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25 September 2017

274

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25 September 2017

27

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25 September 2017

18981-18988

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25 September 2017

Function and activation of NF-kappa B in the immune system

1 reference

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

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I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity

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The NF-kappa B and I kappa B proteins: new discoveries and insights

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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

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Inhibition of NF-kappa B by sodium salicylate and aspirin

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Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

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Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B

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Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

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Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways

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Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.

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Perturbation of biochemical transmethylations by 3-deazaadenosine in vivo

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3-Deaza-adenosine and inhibition of HIV

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Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains

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Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis

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3-Deazaadenosine analogues inhibit the production of tumour necrosis factor-alpha in RAW264.7 cells stimulated with lipopolysaccharide

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Cell death initiated by 3-deazaadenosine in HL-60 cells is apoptosis and is partially inhibited by homocysteine

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

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Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages

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21 January 2018

Autoregulation of I kappa B alpha activity

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21 January 2018

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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21 January 2018

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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21 January 2018

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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21 January 2018

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter

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An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1 reference

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The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

1 reference

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21 January 2018

Effects of the S-adenosylhomocysteine hydrolase inhibitors 3-deazaadenosine and 3-deazaaristeromycin on RNA methylation and synthesis

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21 January 2018

Immunosuppressive effects of the S-adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine

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Imidazo[4,5-c]pyridines (3-deazapurines) and their nucleosides as immunosuppressive and antiinflammatory agents

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Apoptosis of L1210 Leukemia Cells Induced by 3-Deazaadenosine Analogs: Differential Expression of c-myc, NF-Kappa B and Molecular Events

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Effects of 3‐Deazaadenosine on Apoptosis‐Related Gene Transcripts in HL‐60 Cells

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21 January 2018

Identifiers

10.1074/JBC.274.27.18981

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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