Why positive selection? (Q40801745)

23 September 2017

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title

Why positive selection? (English)

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23 September 2017

Matzinger P

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23 September 2017

publication date

1 October 1993

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23 September 2017

published in

Immunological Reviews

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23 September 2017

volume

135

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23 September 2017

page(s)

81-117

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Activation events during thymic selection

23 September 2017

cites work

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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

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The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens

21 January 2018

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T-cell inhibition of humoral responsiveness. II. Theory on the role of restrictive recognition in immune regulation

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Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex

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Patterns of virus-immune T-cell responsiveness. Comparison of (H-2(k) x H-2(b)) {arrow} H-2(b) Radiation Chimeras and negatively selected H-2(b) lymphocytes

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21 January 2018

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Cross-linking of CD4 and CD8 with the T-cell receptor complex: quaternary complex formation and T-cell repertoire selection

21 January 2018

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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

21 January 2018

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Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

21 January 2018

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Mice lacking MHC class II molecules

21 January 2018

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A speculative view of the multicomponent nature of T cell antigen recognition

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Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens

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A fail-safe mechanism for maintaining self-tolerance

21 January 2018

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T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages

21 January 2018

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Specificity of T-cell cones illustrates altered self hypothesis

21 January 2018

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Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells

21 January 2018

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MHC restriction, alloreactivity, and thymic education: a common link?

21 January 2018

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Approaching the asymptote? Evolution and revolution in immunology

21 January 2018

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Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin

21 January 2018

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Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens

21 January 2018

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Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?

21 January 2018

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Does T-cell tolerance require a dedicated antigen-presenting cell?

21 January 2018

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In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type

21 January 2018

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Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes

21 January 2018

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

21 January 2018

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Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

21 January 2018

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In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

21 January 2018

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Sequence analysis of peptides bound to MHC class II molecules

21 January 2018

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Split tolerance induced by the intrathymic adoptive transfer of thymocyte stem cells

21 January 2018

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Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-ficoll. Adaptive differentiation and self-recognition by B cells

21 January 2018

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Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny

21 January 2018

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Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

21 January 2018

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Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

21 January 2018

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Unresponsiveness to a foreign antigen can be caused by self-tolerance

21 January 2018

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Influence of the major histocompatibility complex on lymphocyte interactions in antibody formation

21 January 2018

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CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.

21 January 2018

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Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

21 January 2018

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On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

21 January 2018

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T cell tolerance by clonal elimination in the thymus

21 January 2018

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A critical role of λ5 protein in B cell development

21 January 2018

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Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction.

21 January 2018

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Deletion of self-reactive T cells before entry into the thymus medulla

21 January 2018

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Identification of self peptides bound to purified HLA-B27

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Can B cells turn on virgin T cells?

21 January 2018

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Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Self tolerance is H–2-restricted

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Developmental regulation of T-cell receptor gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Participation of CD4 coreceptor molecules in T-cell repertoire selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

High determinant density may explain the phenomenon of alloreactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Cim: an MHC class II-linked allelism affecting the antigenicity of a classical class I molecule for T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

A one-receptor view of T-cell behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Is self tolerance H-2 restricted?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

A beginner's guide to major histocompatibility complex function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Evidence from in vitro studies that tolerance to self antigens is MHC-restricted

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

Three-receptor, clonal expansion model for selection of self-recognition in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1993.TB00645.X

10.1111/J.1600-065X.1993.TB00645.X

21 January 2018

Identifiers

DOI

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23 September 2017

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