The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome (Q40786423)

23 September 2017

title

The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome (English)

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23 September 2017

main subject

Philadelphia chromosome

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object named as

Philadelphia chromosome

2 August 2024

Kin Y

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23 September 2017

Li G

series ordinal

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23 September 2017

Shibuya M

series ordinal

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23 September 2017

Maru Y

series ordinal

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23 September 2017

language of work or name

English

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publication date

13 August 2001

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

276

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23 September 2017

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23 September 2017

page(s)

39462-39468

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23 September 2017

cites work

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BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

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BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

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Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein

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Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

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A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs

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The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

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Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

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Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation

21 January 2018

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BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.

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The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

21 January 2018

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The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein

21 January 2018

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BCR binds to the xeroderma pigmentosum group B protein

21 January 2018

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Firefly luciferase gene: structure and expression in mammalian cells

21 January 2018

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The BCR gene encodes a novel serine/threonine kinase activity within a single exon

21 January 2018

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The dimerization property of glutathione S-transferase partially reactivates Bcr-Abl lacking the oligomerization domain.

21 January 2018

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Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

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Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

21 January 2018

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JAK-STAT signaling activated by Abl oncogenes

21 January 2018

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Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

21 January 2018

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The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration

21 January 2018

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Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia

21 January 2018

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Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration

21 January 2018

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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

21 January 2018

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Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

21 January 2018

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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

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21 January 2018

Identifiers

DOI

10.1074/JBC.M105484200

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23 September 2017

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