Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? (Q40716277)

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scientific article published on June 2002

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English	Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?	scientific article published on June 2002

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instance of

scholarly article

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Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

title

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? (English)

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Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

main subject

cell line

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author name string

Fuxing Tang

series ordinal

1

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Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

Kazutoshi Horie

series ordinal

2

1 reference

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Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

Ronald T Borchardt

series ordinal

3

1 reference

stated in

Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

publication date

1 June 2002

1 reference

stated in

Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

published in

Pharmaceutical Research

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stated in

Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

volume

19

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stated in

Europe PubMed Central

PubMed publication ID

12134945

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23 September 2017

issue

6

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Europe PubMed Central

PubMed publication ID

12134945

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23 September 2017

page(s)

765-772

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Europe PubMed Central

PubMed publication ID

12134945

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23 September 2017

describes a project that uses

MDCK-MDR1

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cites work

Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

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inferred from PubMed ID database lookup

The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug-resistance phenotype in Chinese hamster ovary cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-dependent pharmacokinetics of cyclosporin A in rats: events in tissues.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

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P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

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The application of cell culture systems in drug discovery and development

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

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Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

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Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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P-Glycoprotein in cell cultures: a combined approach to study expression, localisation, and functionality in the confocal microscope.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

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Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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Multidrug resistance and the role of P-glycoprotein knockout mice

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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Transport of digoxin into brain microvessels and choroid plexuses isolated from guinea pig.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

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Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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Relationship between expression level of P-glycoprotein and daunorubicin transport in LLC-PK1 cells transfected with human MDR1 gene

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of intestinal peptide transport with a protein related to the cadherin superfamily

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sorting of newly synthesized galactosphingolipids to the two surface domains of epithelial cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of P-glycoprotein with defined phospholipid bilayers: a differential scanning calorimetric study

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active secretion and enterocytic drug metabolism barriers to drug absorption

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial sphingolipid sorting allows for extensive variation of the fatty acyl chain and the sphingosine backbone.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partitioning of local anesthetics into membranes: surface charge effects monitored by the phospholipid head-group

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multidrug resistance protein family.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two strains of the Madin-Darby canine kidney (MDCK) cell line have distinct glycosphingolipid compositions.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caco-2 monolayers in experimental and theoretical predictions of drug transport

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12134945

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12 December 2020

based on heuristic

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Identifiers

DOI

10.1023/A:1016140429238

1 reference

stated in

Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

PubMed publication ID

12134945

1 reference

stated in

Europe PubMed Central

PubMed publication ID

12134945

retrieved

23 September 2017

 

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