Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis (Q40653474)

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scientific article published on 6 August 2015

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English	Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis	scientific article published on 6 August 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

22 September 2017

Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis (English)

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PubMed publication ID

22 September 2017

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Streptomyces lincolnensis

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author name string

A-P Pang

1

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Europe PubMed Central

PubMed publication ID

22 September 2017

L Du

2

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PubMed publication ID

22 September 2017

C-Y Lin

3

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PubMed publication ID

22 September 2017

J Qiao

4

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22 September 2017

G-R Zhao

5

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22 September 2017

language of work or name

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publication date

6 August 2015

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22 September 2017

full work available at URL

https://sfamjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jam.12919

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19 March 2024

https://api.unpaywall.org/v2/10.1111/jam.12919?email=unpaywall_01@example.com

Journal of Applied Microbiology

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22 September 2017

119

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22 September 2017

4

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22 September 2017

1064-1074

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22 September 2017

online access status

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19 March 2024

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Genetic improvement of processes yielding microbial products

1 reference

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Strain improvement in actinomycetes in the postgenomic era.

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Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation

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Biochemical characterization of L-DOPA 2,3-dioxygenase, a single-domain type I extradiol dioxygenase from lincomycin biosynthesis

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Defining a kinetic mechanism for l-DOPA 2,3 dioxygenase, a single-domain type I extradiol dioxygenase from Streptomyces lincolnensis.

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Analysis of genes involved in 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraea

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An efficient intergeneric conjugation of DNA from Escherichia coli to mycelia of the lincomycin-producer Streptomyces lincolnensis

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Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces.

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Widespread activation of antibiotic biosynthesis by S-adenosylmethionine in streptomycetes

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Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis

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Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes

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Sequence analysis and heterologous expression of the lincomycin biosynthetic cluster of the type strain Streptomyces lincolnensis ATCC 25466.

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Biosynthesis of sibiromycin, a potent antitumor antibiotic

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Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analog

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In vitro characterization of LmbK and LmbO: identification of GDP-D-erythro-α-D-gluco-octose as a key intermediate in lincomycin A biosynthesis

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Synthetic Biology in Streptomyces Bacteria

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Characterization of N-demethyllincosamide methyltransferases LmbJ and CcbJ.

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Sequence analysis of porothramycin biosynthetic gene cluster

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l-3,4-Dihydroxyphenyl alanine-extradiol cleavage is followed by intramolecular cyclization in lincomycin biosynthesis.

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Lincomycin biosynthesis involves a tyrosine hydroxylating heme protein of an unusual enzyme family

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Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11

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Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN.

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Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes

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Lincomycin, cultivation of producing strains and biosynthesis

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Lincomycin, clindamycin and their applications

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Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis

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21 January 2018

Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis.

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21 January 2018

Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci

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Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

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Lincomycin, rational selection of high producing strain and improved fermentation by amino acids supplementation

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Overexpression of yeast S-adenosylmethionine synthetase metK in Streptomyces actuosus leads to increased production of nosiheptide.

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S-Adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces

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Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A.

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Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis

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Biosynthesis of lincomycin. IV. Origin of methyl groups

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Identifiers

10.1111/JAM.12919

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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