Identification of residues and domains of Raf important for function in vivo and in vitro (Q40637880)

22 September 2017

title

Identification of residues and domains of Raf important for function in vivo and in vitro (English)

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22 September 2017

Angus Harding

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22 September 2017

Virginia Hsu

series ordinal

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22 September 2017

Kerry Kornfeld

series ordinal

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22 September 2017

John F Hancock

series ordinal

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22 September 2017

language of work or name

English

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publication date

3 September 2003

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

278

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22 September 2017

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22 September 2017

page(s)

45519-45527

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Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

22 September 2017

cites work

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C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

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ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

21 January 2018

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MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity

21 January 2018

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Mutational activation of c-raf-1 and definition of the minimal transforming sequence

21 January 2018

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Definition of the human raf amino-terminal regulatory region by deletion mutagenesis

21 January 2018

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Ras-Raf complexes: analyses of complexes formed in vivo

21 January 2018

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Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

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A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

21 January 2018

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p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

1 reference

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p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

21 January 2018

1 reference

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Disruption of Raf-1/heat shock protein 90 complex and Raf signaling by dexamethasone in mast cells.

21 January 2018

1 reference

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Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

21 January 2018

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

1 reference

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14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain

21 January 2018

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Interactions of c-Raf-1 with phosphatidylserine and 14-3-3.

21 January 2018

1 reference

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Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

21 January 2018

1 reference

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Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo.

21 January 2018

1 reference

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14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo

21 January 2018

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MEK kinase activity is not necessary for Raf-1 function

21 January 2018

1 reference

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Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

21 January 2018

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Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

21 January 2018

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Endothelial apoptosis in Braf-deficient mice

21 January 2018

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Craf-1 protein kinase is essential for mouse development.

21 January 2018

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Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

21 January 2018

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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

21 January 2018

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Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.

21 January 2018

1 reference

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Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans

21 January 2018

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Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function

21 January 2018

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Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

21 January 2018

1 reference

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Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

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Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?

21 January 2018

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

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SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans

21 January 2018

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soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling

21 January 2018

1 reference

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The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity

21 January 2018

1 reference

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

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The complexity of Raf-1 regulation

21 January 2018

1 reference

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Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

21 January 2018

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Signal transduction: hanging on a scaffold.

21 January 2018

1 reference

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SIGNAL TRANSDUCTION:Routing MAP Kinase Cascades

21 January 2018

1 reference

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

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Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

21 January 2018

1 reference

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Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

21 January 2018

1 reference

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Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

21 January 2018

1 reference

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Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M303106200

1 reference

22 September 2017

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