Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias (Q40615155)

22 September 2017

title

Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias (English)

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22 September 2017

S Zhao

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22 September 2017

M Konopleva

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22 September 2017

M Cabreira-Hansen

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22 September 2017

Z Xie

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22 September 2017

W Hu

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22 September 2017

M Milella

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22 September 2017

Z Estrov

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22 September 2017

G B Mills

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22 September 2017

M Andreeff

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22 September 2017

publication date

1 February 2004

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

page(s)

267-275

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PI3-kinase inhibition: a target for drug development?

22 September 2017

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TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle

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Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines

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A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

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Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

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Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

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21 January 2018

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Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

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21 January 2018

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Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

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Cytokine-regulated expression of survivin in myeloid leukemia

21 January 2018

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21 January 2018

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PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

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Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway

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7 January 2021

Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

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7 January 2021

Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway

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7 January 2021

Cell-surface exposure of phosphatidylserine correlates with the stage of fludarabine-induced apoptosis in chronic lymphocytic leukemia and expression of apoptosis-regulating genes

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7 January 2021

Gene expression analysis of purified hematopoietic stem cells and committed progenitors

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403220

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30 July 2022

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1006027253

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30 July 2022

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30 July 2022