Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin (Q40568043)

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scientific article published on June 2004

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English	Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin	scientific article published on June 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

author name string

Bin Li

1

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Europe PubMed Central

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21 September 2017

Min Yuan

2

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Europe PubMed Central

PubMed publication ID

21 September 2017

In-Ah Kim

3

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Chi-Ming Chang

4

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21 September 2017

Eric J Bernhard

5

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21 September 2017

Hui-Kuo G Shu

6

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21 September 2017

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publication date

1 June 2004

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21 September 2017

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Europe PubMed Central

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21 September 2017

23

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21 September 2017

26

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21 September 2017

4594-4602

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Europe PubMed Central

PubMed publication ID

21 September 2017

Constitutive Activation of c-Jun N-terminal Kinase by a Mutant Epidermal Growth Factor Receptor

1 reference

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Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells

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Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973–1991

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Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells

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Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

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21 January 2018

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases

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21 January 2018

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

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21 January 2018

Structural alterations of the epidermal growth factor receptor gene in human gliomas

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21 January 2018

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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21 January 2018

Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)

1 reference

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Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults

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Creation of human tumour cells with defined genetic elements

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A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

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Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

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Cell cycle and apoptosis

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Identifiers

10.1038/SJ.ONC.1207602

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

ResearchGate publication ID

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