gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity (Q40379284)

20 September 2017

title

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity (English)

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20 September 2017

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20 September 2017

Kia Strömberg

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20 September 2017

Emil M Hansson

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20 September 2017

Hanna Laudon

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20 September 2017

Susanne Bergstedt

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20 September 2017

Jan Näslund

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20 September 2017

Johan Lundkvist

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20 September 2017

language of work or name

English

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publication date

31 August 2005

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Journal of Neurochemistry

20 September 2017

published in

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20 September 2017

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20 September 2017

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20 September 2017

page(s)

880-890

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Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

20 September 2017

cites work

1 reference

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The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

21 January 2018

1 reference

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Presenilin-1 is located in rat mitochondria

21 January 2018

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Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

21 January 2018

1 reference

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The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

21 January 2018

1 reference

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Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

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A RIP tide in neuronal signal transduction

21 January 2018

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

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Reconstitution of gamma-secretase activity

21 January 2018

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Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

21 January 2018

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

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Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

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A sensitive and quantitative assay for measuring cleavage of presenilin substrates

21 January 2018

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The ins and outs of presenilin 1 membrane topology

21 January 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 January 2018

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Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

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Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

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Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Notch receptor cleavage depends on but is not directly executed by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Intramembrane proteolysis: theme and variations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03415.X

10.1111/J.1471-4159.2005.03415.X

21 January 2018

Identifiers

DOI

1 reference

20 September 2017

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