Serpins prevent granzyme-induced death in a species-specific manner (Q40331824)

19 September 2017

title

Serpins prevent granzyme-induced death in a species-specific manner (English)

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19 September 2017

Michael Bots

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19 September 2017

Liesbeth VAN Bostelen

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19 September 2017

Mirjam Tga Rademaker

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19 September 2017

Rienk Offringa

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19 September 2017

Jan Paul Medema

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19 September 2017

publication date

1 February 2006

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Immunology & Cell Biology

19 September 2017

published in

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19 September 2017

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19 September 2017

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19 September 2017

page(s)

79-86

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Functional significance of the perforin/granzyme cell death pathway

19 September 2017

cites work

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In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

21 January 2018

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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

21 January 2018

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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

21 January 2018

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

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Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

21 January 2018

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

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Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

21 January 2018

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DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

21 January 2018

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

21 January 2018

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Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

21 January 2018

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Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

21 January 2018

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Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

21 January 2018

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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

21 January 2018

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Cell death induced by granzyme C.

21 January 2018

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Granzyme M mediates a novel form of perforin-dependent cell death

21 January 2018

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Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

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Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

21 January 2018

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Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

21 January 2018

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Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

21 January 2018

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Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

21 January 2018

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Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma

21 January 2018

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Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma

21 January 2018

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SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity

21 January 2018

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A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

21 January 2018

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The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells

21 January 2018

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Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B

21 January 2018

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A central role for Bid in granzyme B-induced apoptosis

21 January 2018

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Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

21 January 2018

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Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

21 January 2018

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A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1711.2005.01417.X

Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

21 January 2018

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

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10.1111/J.1440-1711.2005.01417.X

21 January 2018

Identifiers

DOI

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19 September 2017

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