Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone (Q40326657)

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scientific article published on September 1972

Language	Label	Description	Also known as
English	Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone	scientific article published on September 1972

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone (English)

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

supporting evidence

1 reference

based on heuristic

inferred from title

author name string

Oppenheimer JH

1

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Schwartz HL

2

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Surks MI

3

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

language of work or name

0 references

publication date

1 September 1972

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

51

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

2493-2497

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Antigoitrogenic and calorigenic activities of thyroxine analogues in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

The in vivo conversion of thyroxine to 3:5:3'triiodothyronine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

The extrathyroidal conversion rate of thyroxine to triiodothyronine in normal man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Quantitation of extrathyroidal conversion of l-thyroxine to 3,5,3′-triiodo-l-thyronine in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Conversion of Thyroxine to Triiodothyronine in Normal Human Subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Metabolism of Phenolic- and Tyrosyl-Ring Labeled L-Thyroxine in Human Beings and Rats1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Conversion of Thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Evaluation of the peripheral deiodination of L-thyroxine as an index of its thyrotrophin suppressing effectiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Differences in primary cellular factors influencing the metabolism and distribution of 3,5,3'-L-triiodothyronine and L-thyroxine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Specific Triiodothyronine Binding Sites in the Anterior Pituitary of the Rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Influence of 2-thiouracil and thiamazole on the activity of rat liver L-alpha-glycerophosphate oxidase as a function of L-thyroxine, L-3',3,5-triiodothyronine and L-3'-isopropyl-3,5-diiodothyronine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Effect of propylthiouracil and methimazole on the oxygen comsumption of hypothyroid rats receiving thyroxine or triiodothyronine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Effects of Propylthiouracil and Thiouracil on the Metabolism of Thyroxine and Several of Its Derivatives by Rat Kidney Slicesin Vitro1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

2 December 2018

Effect of an anti-thyroxine compound on the metabolism of radioactive thyroxine and triiodothyronine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE IDENTIFICATION OF 3:5:3'-L-TRIIODOTHYRONINE IN HUMAN PLASMA

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of triiodo-L-thyronine and L-thyroxine on the oxygen consumption and body weights of rats fed on a diet containing 0.05 percent propylthiouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of thiouracil on rat liver alpha-glycerophosphate dehydrogenase and serum PBI responses to L-thyroxine

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 3:5:3-L-triiodothyronine and certain anti-thyroxine substances on the oxygen consumption of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALPHA-GLYCEROPHOSPHATE DEHYDROGENASE RESPONSE TO THYROXINE IN THYROIDECTOMIZED, THIOURACIL-FED AND TEMPERATURE-ADAPTED RATS

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propylthiouracil and hepatic clearance of thyroid hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of propylthiouracil, methylthiouracil and thiouracil on the peripheral metabolism of 1-thyroxine in thyroidectomized, 1-thyroxine maintained rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF THE RAT

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

I131 excretion after injection of radiothyroxine into hyperthyroid, hypothyroid or normal rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase of the Rate of Release of Thyroidal Iodine-131 and of Circulating Thyrotrophic Activity at Early Stages of Propylthiouracil Treatment in the Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of the calorigenic activities of certain thyroxine analogues with chronic thiouracil treatment in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal I-131 L-thyroxine metabolism in the presence of potassium perchlorate and interrupted by propylthiouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of propylthiouracil on degradation of I 131-labeled thyroxine and triiodothyronine

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of thiouracil-type drugs on the alpha-glycerophosphate dehydrogenase response to thyroxine analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic effects of thyroxine injected into normal, thiouracil-treated and thyroidectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation Between Thyroxine Metabolism and Hormonal Action in Phenobarbital-Treated Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of propylthiouracil on the thyroxine-thyrotropin interplay

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference with deiodination of some thyroxine analogues in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI107063

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

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