Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways (Q40277182)

19 September 2017

title

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways (English)

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19 September 2017

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19 September 2017

Liu L

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19 September 2017

Li F

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19 September 2017

Cardelli JA

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19 September 2017

Martin KA

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19 September 2017

Blenis J

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19 September 2017

language of work or name

English

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publication date

22 May 2006

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19 September 2017

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19 September 2017

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19 September 2017

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19 September 2017

page(s)

7029-7040

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Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways

19 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

The TOR pathway: a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Urokinase type plasminogen activator receptor is involved in insulin-like growth factor-induced migration of rhabdomyosarcoma cells in vitro.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Regulation of translation initiation by FRAP/mTOR

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Rapamycin inhibits GM-CSF-induced neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

A simplified system for generating recombinant adenoviruses

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Targeting mTOR signaling for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Inhibitory effect of rapamycin on corneal neovascularization in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

The insulin-like growth factor system and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Rapamycin is an effective inhibitor of human renal cancer metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

The expanding TOR signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Insulin-like growth factor I stimulates motility in human neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Rapamycin inhibits vascular smooth muscle cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Cell migration: integrating signals from front to back

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Targeting the molecular target of rapamycin (mTOR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Cell motility assay and inhibition by Rho-GDP dissociation inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

Integrins and E-cadherin cooperate with IGF-I to induce migration of epithelial colonic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

7 January 2021

NO alters cell shape and motility in aortic smooth muscle cells via protein tyrosine phosphatase 1B activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

7 January 2021

Studies on the mechanism of resistance to rapamycin in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

7 January 2021

Putrescine does not support the migration and growth of IEC-6 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209691

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209691

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Dimensions Publication ID

19 September 2017

1021433188

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