Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells. (Q48832449)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190074%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells (English)

1 reference

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2 April 2020

1 reference

neoplastic stem cells

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2 April 2020

author name string

Loruhama Delgado-Rivera

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2 April 2020

Gergana Georgieva

1 reference

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2 April 2020

Gregory R J Thatcher

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2 April 2020

Jonna Frasor

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2 April 2020

publication date

18 January 2017

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Journal of Visualized Experiments

2 April 2020

published in

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2 April 2020

issue

119

1 reference

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Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein

2 April 2020

cites work

1 reference

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A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties.

22 May 2018

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NFκB affects estrogen receptor expression and activity in breast cancer through multiple mechanisms.

22 May 2018

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NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype

22 May 2018

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22 May 2018

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Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling

22 May 2018

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22 May 2018

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Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots

22 May 2018

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The role of breast cancer stem cells in metastasis and therapeutic implications

22 May 2018

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22 May 2018

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The Canonical NF-κB Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion

22 May 2018

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Nonsteroidal Antiinflammatory Drug-Related Injury to the Gastrointestinal Tract: Clinical Picture, Pathogenesis, and Prevention

22 May 2018

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Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation

22 May 2018

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Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer

22 May 2018

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The increasing complexity of the cancer stem cell paradigm

22 May 2018

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Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

22 May 2018

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The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies

22 May 2018

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

22 May 2018

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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

22 May 2018

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22 May 2018

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Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

22 May 2018

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

22 May 2018

1 reference

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IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

22 May 2018

1 reference

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Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer

22 May 2018

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22 May 2018

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Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-kappa B1, but not RelA in normal human dermal fibroblast cells

22 May 2018

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

22 May 2018

1 reference

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Inhibition of NF-kappa B by sodium salicylate and aspirin

22 May 2018

1 reference

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Purification of RNA using TRIzol (TRI reagent).

22 May 2018

1 reference

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Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5352264

Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5352264

Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28190074

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3791/54798

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190074%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190074%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

PubMed publication ID

28190074

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190074%20AND%20SRC:MED&resulttype=core&format=json