Mechanism of action of the bimodal antidepressant vilazodone: evidence for serotonin1A-receptor-mediated auto-augmentation of extracellular serotonin output (Q48371859)

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scientific article published on 14 January 2014

Language	Label	Description	Also known as
English	Mechanism of action of the bimodal antidepressant vilazodone: evidence for serotonin1A-receptor-mediated auto-augmentation of extracellular serotonin output	scientific article published on 14 January 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

Mechanism of action of the bimodal antidepressant vilazodone: evidence for serotonin1A-receptor-mediated auto-augmentation of extracellular serotonin output (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

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author name string

Christoph van Amsterdam

1

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

Christoph A Seyfried

2

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

publication date

14 January 2014

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

number of pages

12

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Psychopharmacology

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

231

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

12

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

2547-2558

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

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In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors

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Electrophysiological evidence for rapid 5-HT₁A autoreceptor inhibition by vilazodone, a 5-HT₁A receptor partial agonist and 5-HT reuptake inhibitor

1 reference

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The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine

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Electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5-HT1A agonists

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Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex

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Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders.

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Biosynthesis of serotonin in Raphé nuclei of rat brain: effect of p-chlorophenylalanine

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1 reference

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Vilazodone, a novel dual-acting serotonergic antidepressant for managing major depression

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A randomized, double-blind, placebo-controlled, 8-week study of vilazodone, a serotonergic agent for the treatment of major depressive disorder

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Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists

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Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder.

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Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist

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The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain

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An automated direct-injection HPLC-method for the electrochemical/fluorimetric quantitation of monoamines and related compounds optimized for the screening of large numbers of animals

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Biochemical and functional studies on EMD 49,980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems

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5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis.

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Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram

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Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons

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The pharmacological characterization of a novel selective 5-hydroxytryptamine1A receptor antagonist, NAD-299

1 reference

https://pubmed.ncbi.nlm.nih.gov/24419272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24419272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135

1 reference

https://pubmed.ncbi.nlm.nih.gov/24419272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EMD 68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT1A receptor agonistic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/24419272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p-Iodoamphetamine as a serotonin depletor in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24419272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential receptor reserve for 5-HT1A receptor-mediated regulation of plasma neuroendocrine hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/24419272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/24419272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiological comparison of 5-Hydroxytryptamine1A receptor antagonists on dorsal raphe cell firing

1 reference

https://pubmed.ncbi.nlm.nih.gov/24419272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-013-3428-7

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/24419272

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