Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. (Q48139357)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29382747%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation (English)

1 reference

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13 March 2020

1 reference

1 reference

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13 March 2020

Brian C Betts

1 reference

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13 March 2020

David Bastian

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13 March 2020

Supinya Iamsawat

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13 March 2020

Jessica L Heinrichs

1 reference

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13 March 2020

Yongxia Wu

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13 March 2020

Anusara Daenthanasanmak

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13 March 2020

Anandharaman Veerapathran

1 reference

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13 March 2020

Alison O'Mahony

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13 March 2020

Kelly Walton

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13 March 2020

Jordan Reff

1 reference

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13 March 2020

Pedro Horna

1 reference

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13 March 2020

Elizabeth M Sagatys

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13 March 2020

Marie C Lee

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13 March 2020

Jack Singer

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13 March 2020

Ying-Jun Chang

1 reference

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13 March 2020

Chen Liu

1 reference

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13 March 2020

Joseph Pidala

1 reference

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13 March 2020

Claudio Anasetti

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13 March 2020

Xue-Zhong Yu

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13 March 2020

language of work or name

English

0 references

publication date

30 January 2018

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

13 March 2020

published in

1 reference

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13 March 2020

volume

115

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13 March 2020

issue

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13 March 2020

page(s)

1582-1587

1 reference

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Targeting the interleukin-1 pathway in patients with hematological disorders

13 March 2020

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Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function.

29 September 2018

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Human Dendritic Cells Mitigate NK-Cell Dysfunction Mediated by Nonselective JAK1/2 Blockade

29 September 2018

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29 September 2018

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IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites

29 September 2018

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ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease.

29 September 2018

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29 September 2018

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Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation

29 September 2018

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In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity

29 September 2018

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Safety and Efficacy of Fedratinib in Patients With Primary or Secondary Myelofibrosis: A Randomized Clinical Trial

29 September 2018

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29 September 2018

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Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects

29 September 2018

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JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms

29 September 2018

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JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasms

29 September 2018

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CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response.

29 September 2018

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Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.

29 September 2018

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Pharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effect

29 September 2018

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The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

29 September 2018

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Phenotypic and functional activation of hyporesponsive KIRnegNKG2Aneg human NK-cell precursors requires IL12p70 provided by Poly(I:C)-matured monocyte-derived dendritic cells

29 September 2018

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29 September 2018

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Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation

29 September 2018

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Expression of α4β7 integrin on memory CD8(+) T cells at the presentation of acute intestinal GVHD.

29 September 2018

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IFNγR signaling mediates alloreactive T-cell trafficking and GVHD

29 September 2018

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STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

29 September 2018

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JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis

29 September 2018

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IL-1β and TGF-β act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells.

29 September 2018

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29 September 2018

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Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen

29 September 2018

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29 September 2018

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Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model.

29 September 2018

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29 September 2018

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The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut.

29 September 2018

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

29 September 2018

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Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

29 September 2018

1 reference

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Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects

29 September 2018

1 reference

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The effect of graft-versus-host disease on T cell production and homeostasis

29 September 2018

1 reference

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The Pathology of full-thickness cadaver skin transplant for large abdominal defects: a proposed grading system for skin allograft acute rejection

29 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29382747

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ustekinumab demonstrates activity in glucocorticoid-refractory acute GVHD

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29382747

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29382747

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1712452115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29382747%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29382747%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

29382747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29382747%20AND%20SRC:MED&resulttype=core&format=json