Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass. (Q48090067)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28546423%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass (English)

1 reference

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21 March 2020

1 reference

1 reference

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21 March 2020

Ernesto Bernal-Mizrachi

1 reference

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21 March 2020

Emilyn U Alejandro

1 reference

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21 March 2020

Manuel Blandino-Rosano

1 reference

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21 March 2020

Michelle Ann Wasan

1 reference

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21 March 2020

Lynda Elghazi

1 reference

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21 March 2020

Suryakiran Vadrevu

1 reference

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21 March 2020

Leslie Satin

1 reference

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21 March 2020

language of work or name

English

0 references

publication date

25 May 2017

1 reference

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21 March 2020

number of pages

1 reference

based on heuristic

inferred from page(s)

published in

Diabetes

1 reference

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21 March 2020

volume

1 reference

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21 March 2020

issue

1 reference

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21 March 2020

page(s)

2150-2162

1 reference

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TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis

21 March 2020

cites work

1 reference

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Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell

26 August 2018

1 reference

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Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring

26 August 2018

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26 August 2018

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Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells

26 August 2018

1 reference

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production

26 August 2018

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mTORC1 signaling and regulation of pancreatic β-cell mass

26 August 2018

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

26 August 2018

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Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size

26 August 2018

1 reference

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Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

26 August 2018

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Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells

26 August 2018

1 reference

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Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases

26 August 2018

1 reference

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Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia

26 August 2018

1 reference

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Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy

26 August 2018

1 reference

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

26 August 2018

1 reference

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Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

26 August 2018

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Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

26 August 2018

1 reference

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MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells

26 August 2018

1 reference

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Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation

26 August 2018

1 reference

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Rapamycin impairs in vivo proliferation of islet beta-cells.

26 August 2018

1 reference

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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome

26 August 2018

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Hypothalamic mTOR signaling regulates food intake

26 August 2018

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Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms

26 August 2018

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Development of a single-cassette system for spatiotemporal gene regulation in mice

26 August 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

26 August 2018

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Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

26 August 2018

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Targeting of the Akt/PKB kinase to the actin skeleton.

26 August 2018

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PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration

26 August 2018

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Increased islet apoptosis in Pdx1+/- mice

26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28546423

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB16-1349

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28546423%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

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21 March 2020

PubMed publication ID

28546423

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28546423%20AND%20SRC:MED&resulttype=core&format=json