Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation. (Q47833797)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Tamara Caspary

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

language of work or name

English

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publication date

29 January 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

13 March 2020

published in

1 reference

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13 March 2020

volume

115

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13 March 2020

issue

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13 March 2020

page(s)

1570-1575

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma

13 March 2020

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1 reference

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Arl13b Promotes Gastric Tumorigenesis by Regulating Smo Trafficking and Activation of the Hedgehog Signaling Pathway

29 September 2018

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Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation

29 September 2018

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29 September 2018

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Arl13b regulates Shh signaling from both inside and outside the cilium.

29 September 2018

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29 September 2018

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Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts

29 September 2018

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Arl13b and the exocyst interact synergistically in ciliogenesis

29 September 2018

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29 September 2018

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Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways

29 September 2018

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Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

29 September 2018

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29 September 2018

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Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation

29 September 2018

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Kif3a is necessary for initiation and maintenance of medulloblastoma

29 September 2018

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ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

29 September 2018

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Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time

29 September 2018

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The clinical implications of medulloblastoma subgroups

29 September 2018

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High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age.

29 September 2018

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Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins

29 September 2018

1 reference

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Gli proteins in development and disease

29 September 2018

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Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory

29 September 2018

1 reference

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Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

29 September 2018

1 reference

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Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Dual and opposing roles of primary cilia in medulloblastoma development

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

29 September 2018

1 reference

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Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

29 September 2018

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Role for primary cilia in the regulation of mouse ovarian function

29 September 2018

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Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

29 September 2018

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Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation

29 September 2018

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Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool

29 September 2018

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The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.

29 September 2018

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A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

29 September 2018

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Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease

29 September 2018

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Patched1 regulates hedgehog signaling at the primary cilium

29 September 2018

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Vagaries of conditional gene targeting

29 September 2018

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The graded response to Sonic Hedgehog depends on cilia architecture

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Development of the post-natal growth plate requires intraflagellar transport proteins

29 September 2018

1 reference

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CellProfiler: image analysis software for identifying and quantifying cell phenotypes

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Cilia and Hedgehog responsiveness in the mouse

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Hedgehog signalling in the mouse requires intraflagellar transport proteins

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Small molecule modulation of Smoothened activity

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Mutations in SUFU predispose to medulloblastoma

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft

29 September 2018

1 reference

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Genetic regulation of cerebellar development

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Residues forming a hydrophobic pocket in ARF3 are determinants of GDP dissociation and effector interactions.

29 September 2018

1 reference

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Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

29 September 2018

1 reference

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Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.

29 September 2018

1 reference

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Activating Smoothened mutations in sporadic basal-cell carcinoma

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Math1 is essential for genesis of cerebellar granule neurons

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5816136

Cilia Proteins Control Cerebellar Morphogenesis by Promoting Expansion of the Granule Progenitor Pool

29 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29378965

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

RETRACTED: A mathematical model explains saturating axon guidance responses to molecular gradients.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.7554/ELIFE.12248

Identifiers

DOI

10.1073/PNAS.1706977115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

29378965

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29378965%20AND%20SRC:MED&resulttype=core&format=json