Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase. (Q47436128)

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9 April 2020

title

Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase (English)

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9 April 2020

main subject

protein ubiquitination

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Brittany M Johnson

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9 April 2020

Russell A DeBose-Boyd

series ordinal

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9 April 2020

publication date

7 November 2017

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Seminars in Cell & Developmental Biology

9 April 2020

published in

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9 April 2020

volume

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9 April 2020

page(s)

121-128

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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

9 April 2020

cites work

1 reference

12 December 2020

Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway

1 reference

12 December 2020

The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

12 December 2020

The sterol-sensing domain: multiple families, a unique role?

1 reference

12 December 2020

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

12 December 2020

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

12 December 2020

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

1 reference

12 December 2020

Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

1 reference

12 December 2020

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

1 reference

12 December 2020

Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.

1 reference

12 December 2020

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

12 December 2020

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

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12 December 2020

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

1 reference

12 December 2020

Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

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12 December 2020

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

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12 December 2020

Protein sensors for membrane sterols

1 reference

12 December 2020

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78

1 reference

12 December 2020

Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy

1 reference

12 December 2020

Mutations in the UBIAD1 gene on chromosome short arm 1, region 36, cause Schnyder crystalline corneal dystrophy.

1 reference

12 December 2020

AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential

1 reference

12 December 2020

Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance

1 reference

12 December 2020

Inhibition of degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo by cysteine protease inhibitors.

1 reference

12 December 2020

Regulation of the mevalonate pathway

1 reference

12 December 2020

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

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12 December 2020

Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol

1 reference

12 December 2020

Evolutionary relationships of microbial aromatic prenyltransferases

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12 December 2020

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

1 reference

12 December 2020

Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis

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12 December 2020

The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes

1 reference

12 December 2020

Lack of effect of lovastatin therapy on the parameters of whole-body cholesterol metabolism

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12 December 2020

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells

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12 December 2020

Structural Insights into Ubiquinone Biosynthesis in Membranes

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12 December 2020

Phenotype-genotype correlation in patients with Schnyder corneal dystrophy.

1 reference

12 December 2020

Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1 reference

12 December 2020

Structure of a membrane-embedded prenyltransferase homologous to UBIAD1

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12 December 2020

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

1 reference

12 December 2020

A century of cholesterol and coronaries: from plaques to genes to statins

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12 December 2020

Bringing Bioactive Compounds into Membranes: The UbiA Superfamily of Intramembrane Aromatic Prenyltransferases

1 reference

12 December 2020

Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi

1 reference

12 December 2020

Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver

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12 December 2020

Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

1 reference

12 December 2020

Identification of the First De Novo UBIAD1 Gene Mutation Associated with Schnyder Corneal Dystrophy.

1 reference

12 December 2020

The membrane domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto beta-galactosidase.

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12 December 2020

A receptor-mediated pathway for cholesterol homeostasis

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12 December 2020

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum

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12 December 2020

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

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12 December 2020

Turnover rate of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by use of cycloheximide

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12 December 2020

In vivo demonstration of the circadian thythm of cholesterol biosynthesis in the liver and intestine of the rat.

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12 December 2020

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1 reference

12 December 2020

Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance

1 reference

12 December 2020

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase

1 reference

12 December 2020

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth

1 reference

12 December 2020

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

1 reference

12 December 2020

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

1 reference

12 December 2020

10.1016/J.SEMCDB.2017.10.019

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29107682%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29107682%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

PubMed publication ID

29107682

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29107682%20AND%20SRC:MED&resulttype=core&format=json