Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores. (Q47416768)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29125762%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

title

Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores (English)

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1 April 2020

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1 April 2020

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1 April 2020

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1 April 2020

Suzy Griffin

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1 April 2020

Michelle Taylor

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1 April 2020

Chi-Chang Weng

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1 April 2020

Kuiying Xu

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1 April 2020

Daniel A Jacome

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1 April 2020

Robert R Luedtke

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1 April 2020

language of work or name

English

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publication date

21 November 2017

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Journal of Medicinal Chemistry

1 April 2020

published in

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volume

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issue

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1 April 2020

page(s)

9905-9910

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Novel, Selective, and Developable Dopamine D3 Antagonists with a Modified "Amino" Region.

1 April 2020

cites work

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Pd-Catalyzed Synthesis of Piperazine Scaffolds Under Aerobic and Solvent-Free Conditions.

26 August 2018

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In Vitro and In Vivo Characterization of Selected Fluorine-18 Labeled Radioligands for PET Imaging of the Dopamine D3 Receptor.

26 August 2018

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1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists

26 August 2018

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26 August 2018

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1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists

26 August 2018

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Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists.

26 August 2018

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Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis

26 August 2018

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Four-membered ring-containing spirocycles: synthetic strategies and opportunities

26 August 2018

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26 August 2018

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Occupancy of brain dopamine D3 receptors and drug craving: a translational approach.

26 August 2018

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Medication discovery for addiction: translating the dopamine D3 receptor hypothesis

26 August 2018

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Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

26 August 2018

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Recent advances in the development of dopamine D3 receptor antagonists: a medicinal chemistry perspective.

26 August 2018

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

26 August 2018

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Current perspectives on the selective regulation of dopamine D2 and D3 receptors

26 August 2018

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Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methods

26 August 2018

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Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists

26 August 2018

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Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.

26 August 2018

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Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders

26 August 2018

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26 August 2018

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1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists

26 August 2018

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26 August 2018

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Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

26 August 2018

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26 August 2018

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26 August 2018

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Characterization of (125)I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors

26 August 2018

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Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons

26 August 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

26 August 2018

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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

26 August 2018

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Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29125762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29125762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACS.JMEDCHEM.7B01248

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29125762%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

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1 April 2020

PubMed publication ID

29125762

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29125762%20AND%20SRC:MED&resulttype=core&format=json