Generating genetically modified mice using CRISPR/Cas-mediated genome engineering (Q46861803)

25 December 2017

title

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering (English)

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25 December 2017

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Rudolf Jaenisch

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25 December 2017

Hui Yang

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Haoyi Wang

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25 December 2017

publication date

24 July 2014

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25 December 2017

published in

Nature Protocols

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25 December 2017

volume

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25 December 2017

issue

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25 December 2017

page(s)

1956-1968

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25 December 2017

describes a project that uses

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Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Targeted genome modification in mice using zinc-finger nucleases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Knockout rats via embryo microinjection of zinc-finger nucleases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Whole-rat conditional gene knockout via genome editing

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Targeted integration in rat and mouse embryos with zinc-finger nucleases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Knockout rats generated by embryo microinjection of TALENs.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Efficient TALEN-mediated gene knockout in livestock

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Generation of gene-modified mice via Cas9/RNA-mediated gene targeting

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Heritable gene targeting in the mouse and rat using a CRISPR-Cas system.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Efficient genome editing in zebrafish using a CRISPR-Cas system

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

CRISPR/Cas, the immune system of bacteria and archaea

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

RNA-guided genetic silencing systems in bacteria and archaea

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

DNA targeting specificity of RNA-guided Cas9 nucleases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Genome engineering using the CRISPR-Cas9 system

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Pronuclear injection for the production of transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

A transgenic mouse strain expressing four drug-selectable marker genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Somatic cell nuclear transfer and derivation of embryonic stem cells in the mouse

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

A rapid and general assay for monitoring endogenous gene modification

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

Knockout mice created by TALEN-mediated gene targeting

21 January 2018

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https://api.crossref.org/works/10.1038%2FNPROT.2014.134

31 March 2020

Identifiers

DOI

10.1038/NPROT.2014.134

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25 December 2017

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25 December 2017