Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate (Q46279925)

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scientific article published on 22 September 2015

Language	Label	Description	Also known as
English	Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate	scientific article published on 22 September 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26391310

Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate. (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26391310

author name string

Mohd Parvez Khan

1

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Atul Kumar Singh

2

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Abhishek Kumar Singh

3

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Pragya Shrivastava

4

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Mahesh Chandra Tiwari

5

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http://europepmc.org/abstract/MED/26391310

Geet Kumar Nagar

6

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Himangshu Kousik Bora

7

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Venkitanarayanan Parameswaran

8

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http://europepmc.org/abstract/MED/26391310

Sabyasachi Sanyal

9

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Jayesh R Bellare

10

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Naibedya Chattopadhyay

11

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21 December 2017

http://europepmc.org/abstract/MED/26391310

publication date

22 September 2015

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21 December 2017

http://europepmc.org/abstract/MED/26391310

Journal of Bone and Mineral Research

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21 December 2017

http://europepmc.org/abstract/MED/26391310

31

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3

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615-629

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http://europepmc.org/abstract/MED/26391310

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts

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https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Isolated osteoclasts resorb the organic and inorganic components of bone

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https://api.crossref.org/works/10.1002%2FJBMR.2719

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Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency

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The bone resorption inhibitors odanacatib and alendronate affect post-osteoclastic events differently in ovariectomized rabbits

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https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits

1 reference

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21 January 2018

Bone density, strength, and formation in adult cathepsin K (-/-) mice

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https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Human osteoblasts produce cathepsin K.

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https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Cathepsin K inhibitors: a novel target for osteoporosis therapy

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https://api.crossref.org/works/10.1002%2FJBMR.2719

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Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Attenuation of osteoclastogenesis and osteoclast function by apigenin

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https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

A novel flavonoid C-glucoside from Ulmus wallichiana preserves bone mineral density, microarchitecture and biomechanical properties in the presence of glucocorticoid by promoting osteoblast survival: a comparative study with human parathyroid hormon

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Evaluation of Cameroonian plants towards experimental bone regeneration.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

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Sulforhodamine B colorimetric assay for cytotoxicity screening

1 reference

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21 January 2018

Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Enhanced immunoprotective effects by anti-IL-17 antibody translates to improved skeletal parameters under estrogen deficiency compared with anti-RANKL and anti-TNF-α antibodies.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Residual strength of equine bone is not reduced by intense fatigue loading: implications for stress fracture

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Positive skeletal effects of cladrin, a naturally occurring dimethoxydaidzein, in osteopenic rats that were maintained after treatment discontinuation

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Ca/P concentration ratio at different sites of normal and osteoporotic rabbit bones evaluated by Auger and energy dispersive X-ray spectroscopy

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Mineral maturity and crystallinity index are distinct characteristics of bone mineral

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

The bone mineralization density distribution as a fingerprint of the mineralization process

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells

1 reference

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21 January 2018

Age-related bone loss: old bone, new facts

1 reference

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21 January 2018

Characterization of a new experimental model of osteoporosis in rabbits

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Bone architecture: collagen structure and calcium/phosphorus maps

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.2719

21 January 2018

Standardized Three-Dimensional Volumes of Interest with Adapted Surfaces for More Precise Subchondral Bone Analyses by Micro-Computed Tomography

1 reference

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21 January 2018

Identifiers

10.1002/JBMR.2719

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26391310

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26391310

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