Asenapine elevates cortical dopamine, noradrenaline and serotonin release. Evidence for activation of cortical and subcortical dopamine systems by different mechanisms (Q46130784)

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scientific article published on 7 February 2009

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English	Asenapine elevates cortical dopamine, noradrenaline and serotonin release. Evidence for activation of cortical and subcortical dopamine systems by different mechanisms	scientific article published on 7 February 2009

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

Asenapine elevates cortical dopamine, noradrenaline and serotonin release. Evidence for activation of cortical and subcortical dopamine systems by different mechanisms (English)

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

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Olivia Frånberg

1

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

Monica M Marcus

2

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PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

Vladimir Ivanov

3

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PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

Björn Schilström

4

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PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

Mohammed Shahid

5

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PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

Torgny H Svensson

6

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

publication date

7 February 2009

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

number of pages

14

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Psychopharmacology

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PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

204

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PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

2

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

251-264

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

Prazosin modulates the changes in firing pattern and transmitter release induced by raclopride in the mesolimbic, but not in the nigrostriatal dopaminergic system

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1456-5

21 January 2018

Idazoxan preferentially increases dopamine output in the rat medial prefrontal cortex at the nerve terminal level

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1456-5

21 January 2018

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1456-5

21 January 2018

The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1456-5

21 January 2018

Thymosthenic agents, a novel approach in the treatment of schizophrenia

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Clonidine modulates dopamine cell firing in rat ventral tegmental area

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Combined alpha2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat.

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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N-methyl-d-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Evidence that systemically administered dopamine antagonists activate dopamine neuron firing primarily by blockade of somatodendritic autoreceptors.

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Asenapine restores cognitive flexibility in rats with medial prefrontal cortex lesions

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Prefrontal neurons and the genetics of schizophrenia

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Tuning the engine of cognition: a focus on NMDA/D1 receptor interactions in prefrontal cortex

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals

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https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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D(1) receptors in prefrontal cells and circuits

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Enhanced cortical dopamine output and antipsychotic-like effects of raclopride by alpha2 adrenoceptor blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A meta-analysis of the efficacy of second-generation antipsychotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Clozapine decreases serotonin extracellular levels in the nucleus accumbens by a dopamine receptor-independent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Nicotinic effects on the firing pattern of midbrain dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Diminished responses of nigral dopaminergic neurons to haloperidol and morphine following lesions in the striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Catalepsy as a rodent model for detecting antipsychotic drugs with extrapyramidal side effect liability

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Clozapine potently stimulates mesocortical dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Increased baseline occupancy of D2 receptors by dopamine in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Schizophrenia: more evidence for less glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

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The control of firing pattern in nigral dopamine neurons: burst firing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

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Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

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The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential actions of typical and atypical antipsychotic drugs on dopamine release in the core and shell of the nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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In vivo characterization of locally applied dopamine uptake inhibitors by striatal microdialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Putting the 'A' in atypical: does α2-adrenoceptor antagonism account for the therapeutic advantage of new antipsychotics?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

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Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

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Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic administration of amperozide, a new atypical antipsychotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of acute clozapine and haloperidol on the activity of ventral tegmental (A10) and nigrostriatal (A9) dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of alpha2-adrenoceptor autoregulation of noradrenaline release in rat nucleus accumbens slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of ORG 5222 as a novel psychotropic agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of amphetamine on single cell activity in a catecholamine nucleus, the locus coeruleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ritanserin potentiates the stimulatory effects of raclopride on neuronal activity and dopamine release selectivity in the mesolimbic dopaminergic system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of clozapine on the activity of central dopaminergic and noradrenergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioural pharmacology of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro- 1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrolidine maleate, a compound interacting with dopaminergic and serotonergic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of antipsychotic-like properties of the dopamine D2 receptor antagonist, raclopride, by the additional treatment with the 5-HT2 receptor blocking agent, ritanserin, in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

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Galantamine enhances dopaminergic neurotransmission in vivo via allosteric potentiation of nicotinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presynaptic nicotinic modulation of dopamine release in the three ascending pathways studied by in vivo microdialysis: comparison of naive and chronic nicotine-treated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risperidone inhibits 5‐hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5‐hydroxytryptamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asenapine: a novel psychopharmacologic agent with a unique human receptor signature

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The revised dopamine hypothesis of schizophrenia: evidence from pharmacological MRI studies with atypical antipsychotic medication.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical effects in brain of low doses of haloperidol are qualitatively similar to those of high doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute haloperidol increases impulse activity of brain noradrenergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of extracellular dopamine by the norepinephrine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of atypical antipsychotic drugs on dopamine output in the shell and core of the nucleus accumbens: role of 5-HT(2A) and alpha(1)-adrenoceptor antagonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Idazoxan, an alpha 2 antagonist, augments fluphenazine in schizophrenic patients: a pilot study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prazosin modulates the firing pattern of dopamine neurons in rat ventral tegmental area

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism at 5-HT(2A) receptors potentiates the effect of haloperidol in a conditioned avoidance response task in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Origin of extracellular dopamine from dopamine and noradrenaline neurons in the medial prefrontal and occipital cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that extracellular concentrations of dopamine are regulated by noradrenergic neurons in the frontal cortex of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presynaptic alpha-2 adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline release (as measured by in vivo dialysis) in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Idazoxan and response to typical neuroleptics in treatment-resistant schizophrenia. Comparison with the atypical neuroleptic, clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of nicotine on levels of extracellular amino acids in regions of the rat brain in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective blockade of serotonin2C/2B receptors enhances dopamine release in the rat nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced efficacy of both typical and atypical antipsychotic drugs by adjunctive alpha2 adrenoceptor blockade: experimental evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-008-1456-5

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/19198810

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