Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs (Q46055612)

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English	Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs	scientific article

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Europe PubMed Central

PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

title

Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs (English)

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

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Kazuhiro Umeyama

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1

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

Masahito Watanabe

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2

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

Hitoshi Saito

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3

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

Mayuko Kurome

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4

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19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

Sadaaki Tohi

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5

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

Hitomi Matsunari

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6

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

Keizaburo Miki

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7

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

Hiroshi Nagashima

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8

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Europe PubMed Central

PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

publication date

9 April 2009

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

published in

Transgenic Research

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PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

volume

18

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Europe PubMed Central

PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

issue

5

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Europe PubMed Central

PubMed publication ID

19357985

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19 December 2017

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http://europepmc.org/abstract/MED/19357985

page(s)

697-706

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PubMed publication ID

19357985

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19 December 2017

reference URL

http://europepmc.org/abstract/MED/19357985

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Mild streptozotocin diabetes in the Göttingen minipig. A novel model of moderate insulin deficiency and diabetes

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Detection of Y-bearing porcine spermatozoa by in situ hybridization using digoxigenin-labeled, porcine male-specific DNA probe produced by polymerase chain reaction

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12 December 2020

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The production of a diabetic mouse using constructs encoding porcine insulin promoter-driven mutant human hepatocyte nuclear factor-1alpha.

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12 December 2020

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Clinical usefulness of serum 1,5-anhydroglucitol in monitoring glycaemic control

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12 December 2020

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Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

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A rare and often unrecognized cerebromeningitis and hemodynamic disorder: a major cause of sudden death in somatic cell cloned piglets.

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Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer

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12 December 2020

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Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas

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12 December 2020

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Nonsense-mediated mRNA decay in health and disease

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12 December 2020

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Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay

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12 December 2020

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Advances in swine biomedical model genomics

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Type 1 and type 2 diabetes: what do they have in common?

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Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction

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12 December 2020

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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

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12 December 2020

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Liver and kidney function in Japanese patients with maturity-onset diabetes of the young

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12 December 2020

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Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

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12 December 2020

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Culture of pig embryos.

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12 December 2020

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Production efficiency and telomere length of the cloned pigs following serial somatic cell nuclear transfer

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Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN

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Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations

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PubMed

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12 December 2020

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Production of cloned pigs from adult somatic cells by chemically assisted removal of maternal chromosomes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19357985

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12 December 2020

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Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19357985

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12 December 2020

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Transgenic swine for biomedicine and agriculture

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19357985

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12 December 2020

based on heuristic

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Environmental triggers and determinants of type 1 diabetes

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PubMed

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12 December 2020

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Effects of sperm pretreatment on efficiency of ICSI-mediated gene transfer in pigs

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19357985

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12 December 2020

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Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19357985

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma 1,5-anhydro-D-glucitol as new clinical marker of glycemic control in NIDDM patients

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19357985

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Pancreatic .BETA.-cell Function by the HNF Transcription Network: Lessons from Maturity-Onset Diabetes of the Young (MODY)

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19357985

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12 December 2020

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Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19357985

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19357985

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19357985

retrieved

12 December 2020

based on heuristic

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Estimation of plasma glucose fluctuation with a combination test of hemoglobin A1c and 1,5-anhydroglucitol

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19357985

retrieved

12 December 2020

based on heuristic

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Identifiers

DOI

10.1007/S11248-009-9262-3

1 reference

stated in

Europe PubMed Central

PubMed publication ID

19357985

retrieved

19 December 2017

reference URL

http://europepmc.org/abstract/MED/19357985

PubMed publication ID

19357985

1 reference

stated in

Europe PubMed Central

PubMed publication ID

19357985

retrieved

19 December 2017

reference URL

http://europepmc.org/abstract/MED/19357985

 

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