Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete (Q46046762)

19 December 2017

title

Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete (English)

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19 December 2017

author name string

Paloma Liras

series ordinal

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19 December 2017

Arnold L Demain

series ordinal

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19 December 2017

language of work or name

English

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publication date

1 January 2009

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19 December 2017

published in

Methods in Enzymology

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19 December 2017

volume

458

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19 December 2017

page(s)

401-429

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19 December 2017

pcd mutants of Streptomyces clavuligerus still produce cephamycin C.

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beta-Lactam synthetase: a new biosynthetic enzyme

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Chemistry and biosynthesis of clavulanic acid and other clavams

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Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG.

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A heuristic approach to the analysis of enzymic catalysis: reaction of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-allylglycine catalyzed by isopenicillin N synthase isozymes

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Ferrous active site of isopenicillin N synthase: genetic and sequence analysis of the endogenous ligands

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Evolution of beta-lactam biosynthesis genes and recruitment of trans-acting factors

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Naturally-occurring beta-lactamase inhibitors with antibacterial activity

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Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway

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7 January 2021

A complete library of amino acid alterations at N304 in Streptomyces clavuligerus deacetoxycephalosporin C synthase elucidates the basis for enhanced penicillin analogue conversion

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7 January 2021

C-terminus modification of Streptomyces clavuligerus deacetoxycephalosporin C synthase improves catalysis with an expanded substrate specificity

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The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function

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Overexpression of the Nocardia lactamdurans alpha-aminoadipyl-cysteinyl-valine synthetase in Streptomyces lividans. The purified multienzyme uses cystathionine and 6-oxopiperidine 2-carboxylate as substrates for synthesis of the tripeptide

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7 January 2021

Characterization of the cefF gene of Nocardia lactamdurans encoding a 3'-methylcephem hydroxylase different from the 7-cephem hydroxylase

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7 January 2021

A two-protein component 7 alpha-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin C to 7-methoxycephalosporin C.

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7 January 2021

A gene encoding lysine 6-aminotransferase, which forms the beta-lactam precursor alpha-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans

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7 January 2021

The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum

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7 January 2021

Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus

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7 January 2021

Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3'-hydroxymethylcephem O-carbamoyltransferase for cephamycin biosynthesis

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7 January 2021

The beta-lactam antibiotics: past, present, and future

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7 January 2021

Further studies on the cyclization of the unnatural tripeptide delta-(D-alpha-aminoadipyl)-L-cysteinyl-D-valine to penicillin N

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7 January 2021

Production of Streptomyces clavuligerus isopenicillin N synthase in Escherichia coli using two-cistron expression systems

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7 January 2021

Interaction of the two proteins of the methoxylation system involved in cephamycin C biosynthesis. Immunoaffinity, protein cross-linking, and fluorescence spectroscopy studies

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7 January 2021

Performance of a recombinant strain of Streptomyces lividans for bioconversion of penicillin G to deacetoxycephalosporin G

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7 January 2021

Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus

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7 January 2021

Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp

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7 January 2021

A complete library of amino acid alterations at R306 in Streptomyces clavuligerus deacetoxycephalosporin C synthase demonstrates its structural role in the ring-expansion activity

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7 January 2021

Relevant double mutations in bioengineered Streptomyces clavuligerus deacetoxycephalosporin C synthase result in higher binding specificities which improve penicillin bioconversion

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7 January 2021

Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides

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7 January 2021

Family shuffling of expandase genes to enhance substrate specificity for penicillin G.

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7 January 2021

Purification of isopenicillin N synthetase from Streptomyces clavuligerus

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7 January 2021

Synthesis of benzylpenicillin by cell-free extracts from Streptomyces clavuligerus

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7 January 2021

Partial purification and characterization of isopenicillin N epimerase activity from Streptomyces clavuligerus

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7 January 2021

Purification and partial characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus

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7 January 2021

Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties

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7 January 2021

L-lysine epsilon-aminotransferase involved in cephamycin C synthesis in Streptomyces lactamdurans

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7 January 2021

Conversion of penicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium

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7 January 2021

Cloning and sequencing of the beta-lactam hydroxylase gene (cefF) from Streptomyces clavuligerus: gene duplication may have led to separate hydroxylase and expandase activities in the actinomycetes

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7 January 2021

The beta-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerus

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7 January 2021

Structure-function studies of the non-heme iron active site of isopenicillin N synthase: some implications for catalysis

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7 January 2021

Purification and characterization of the isopenicillin N epimerase from Nocardia lactamdurans

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7 January 2021

The glutamine ligand in the ferrous iron active site of isopenicillin N synthase of Streptomyces jumonjinensis is not essential for catalysis

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7 January 2021

The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase

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7 January 2021

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258

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7 January 2021

Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)

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7 January 2021

The Effect of Cysteine Mutations on Recombinant Deacetoxycephalosporin C Synthase from S. clavuligerus

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7 January 2021

Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from Streptomyces clavuligerus

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7 January 2021

Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases

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7 January 2021

The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase

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7 January 2021

Biosynthesis and molecular genetics of cephamycins. Cephamycins produced by actinomycetes

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7 January 2021

Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus.

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7 January 2021

Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics

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7 January 2021

Studies on the active site of deacetoxycephalosporin C synthase

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7 January 2021

Site-directed mutagenesis of arginine-89 supports the role of its guanidino side-chain in substrate binding by Cephalosporium acremonium isopenicillin N synthase

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7 January 2021

Cloning and location of a gene governing lysine epsilon-aminotransferase, an enzyme initiating beta-lactam biosynthesis in Streptomyces spp.

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7 January 2021

Crystal structure of carbapenam synthetase (CarA)

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7 January 2021

.beta.-Lactam antibiotics from Streptomyces

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7 January 2021

The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya

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7 January 2021

Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus

1 reference

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7 January 2021

Transcriptional analysis of the isopenicillin N synthase-encoding gene of Streptomyces clavuligerus

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7 January 2021

Improved expression of a hybrid Streptomyces clavuligerus cefE gene in Penicillium chrysogenum

1 reference

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7 January 2021

Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904816-2

7 January 2021

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation

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7 January 2021

Purification and initial characterization of deacetoxycephalosporin C synthase from Streptomyces clavuligerus

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7 January 2021

Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus

1 reference

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7 January 2021

CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904816-2

7 January 2021

Enzymatic characterisation of the multifunctional enzyme delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus

1 reference

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7 January 2021

Cloning and comparative sequence analysis of the gene coding for isopenicillin N synthase in Streptomyces

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7 January 2021

Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. n

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7 January 2021

Purification and characterization of δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine synthetase from Penicillium chrysogenum

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904816-2

7 January 2021

A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum.

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7 January 2021

Purification and properties of isopenicillin N epimerase from Streptomyces clavuligerus

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7 January 2021

Structure of a cephalosporin synthase

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7 January 2021

Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904816-2

7 January 2021

Engineering Streptomyces clavuligerus deacetoxycephalosporin C synthase for optimal ring expansion activity toward penicillin G

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7 January 2021

Enzymatic approach to syntheses of unnatural beta-lactams

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7 January 2021

The invariant F283 and its strategic position in the hydrophobic cleft of Streptomyces jumonjinensis isopenicillin N synthase active site are functionally important.

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7 January 2021

Purification and characterization of cephalosporin 7α-hydroxylase from Streptomyces clavuligerus

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7 January 2021

Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904816-2

7 January 2021

Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904816-2

7 January 2021

A pure enzyme catalyzing penicillin biosynthesis

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7 January 2021

Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.

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7 January 2021

10.1016/S0076-6879(09)04816-2

Identifiers

DOI

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19 December 2017

1 reference

19 December 2017