Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. (Q45969254)

18 December 2017

title

Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. (English)

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18 December 2017

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King C

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18 December 2017

Mueller Hoenger R

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18 December 2017

Malo Cleary M

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18 December 2017

Murali-Krishna K

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18 December 2017

Ahmed R

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18 December 2017

King E

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18 December 2017

Sarvetnick N

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18 December 2017

language of work or name

English

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publication date

1 February 2001

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18 December 2017

published in

Nature Medicine

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18 December 2017

volume

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18 December 2017

issue

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18 December 2017

page(s)

206-214

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18 December 2017

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

cites work

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7 January 2021

Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?

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Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice

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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

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CD28/B7 system of T cell costimulation

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Co-stimulation in T cell responses.

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Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

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CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

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CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

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Cross-linking of T-cell receptors is insufficient to induce IL-2 responsiveness (activation) in resting Lyt-2+ T cells. IL-4 or RIF are essential as second signal

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Regulation of human T-cell proliferation and CTL development by human recombinant interleukin-4

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rIL-4 differentially regulates rIL-2-induced murine NK and LAK killing in CD8+ and CD8- precursor cell subsets

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Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.

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Role of antigen-presenting cells in mediating tolerance and autoimmunity

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

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7 January 2021

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

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7 January 2021

T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

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7 January 2021

Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity

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Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

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Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses

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B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

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Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL

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Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model

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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

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New perspectives of CD28-B7-mediated T cell costimulation

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Sharing of a common gamma chain, gamma c, by the IL-2, IL-4, and IL-7 receptors: implications for X-linked severe combined immunodeficiency (XSCID).

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B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus

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Costimulation of T cells for tumor immunity.

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Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

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7 January 2021

Inhibition of proliferation without affecting the generation of cytotoxicity in the human mixed lymphocyte reaction.

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Antigen-presenting cells for CD8+ T cells

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7 January 2021

Activation of human peripheral blood dendritic cells induces the CD86 co-stimulatory molecule

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Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains

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Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations

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Identifiers

DOI

10.1038/84659

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18 December 2017

Dimensions Publication ID

1019205316

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18 December 2017