Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors (Q45838952)

16 December 2017

title

Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors (English)

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16 December 2017

author

Jens Damsgaard Mikkelsen

series ordinal

object named as

Jens D Mikkelsen

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16 December 2017

Morten S Thomsen

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16 December 2017

language of work or name

English

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publication date

16 August 2012

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16 December 2017

Journal of Neurochemistry

number of pages

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published in

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16 December 2017

volume

123

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16 December 2017

issue

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16 December 2017

page(s)

73-83

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16 December 2017

Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Mammalian nicotinic acetylcholine receptors: from structure to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Human alpha 7 nicotinic acetylcholine receptor responses to novel ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Coupling of ionic events to protein kinase signaling cascades upon activation of alpha7 nicotinic receptor: cooperative regulation of alpha2-integrin expression and Rho kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Regulation of nicotinic receptor expression by the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Allosteric modulators of the alpha7 nicotinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Initial phase 2 trial of a nicotinic agonist in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Increased nicotinic acetylcholine receptor protein underlies chronic nicotine-induced up-regulation of nicotinic agonist binding sites in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Guidelines on nicotine dose selection for in vivo research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Cellular distribution of the nicotinic acetylcholine receptor alpha7 subunit in rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

A comparative study of the effects of the intravenous self-administration or subcutaneous minipump infusion of nicotine on the expression of brain neuronal nicotinic receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Nicotinic acetylcholine receptor alpha7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

An autoradiographic analysis of [125I]alpha-bungarotoxin binding in rat brain after chronic nicotine exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

The α7 nicotinic acetylcholine receptor complex: one, two or multiple drug targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Ultra-low exposure to α-7 nicotinic acetylcholine receptor partial agonists elicits an improvement in cognition that corresponds with an increase in α-7 receptor expression in rodents: implications for low dose clinical efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07876.X

10.1111/J.1471-4159.2012.07876.X

21 January 2018

Identifiers

DOI

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16 December 2017

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16 December 2017