Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease. (Q45297446)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623015%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

title

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease (English)

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22 March 2020

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Eduardo E Arteaga-Bracho

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22 March 2020

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22 March 2020

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22 March 2020

Solen Gokhan

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22 March 2020

Maria Gulinello

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22 March 2020

Michael L Winchester

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22 March 2020

Nandini Pichamoorthy

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22 March 2020

Alicia D Zambrano

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22 March 2020

Julio Inocencio

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22 March 2020

Chirstopher D De Jesus

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22 March 2020

Joseph O Louie

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22 March 2020

Mark F Mehler

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22 March 2020

language of work or name

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10 September 2016

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22 March 2020

published in

Neurobiology of Disease

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22 March 2020

volume

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22 March 2020

page(s)

144-155

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Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation

22 March 2020

cites work

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Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease

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Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.

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RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

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Neuropsychiatry and White Matter Microstructure in Huntington's Disease

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Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice

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Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

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Deep white matter in Huntington's disease

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The Neuropathology of Huntington's Disease

25 May 2018

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Regional atrophy associated with cognitive and motor function in prodromal Huntington disease

25 May 2018

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Cortical interneuron loss and symptom heterogeneity in Huntington disease

25 May 2018

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Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex

25 May 2018

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Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years

25 May 2018

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Functions of huntingtin in germ layer specification and organogenesis

25 May 2018

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Selective roles of normal and mutant huntingtin in neural induction and early neurogenesis

25 May 2018

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Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

25 May 2018

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Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

25 May 2018

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Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

25 May 2018

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Seizures in juvenile Huntington's disease: frequency and characterization in a multicenter cohort

25 May 2018

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Excitotoxicity: bridge to various triggers in neurodegenerative disorders

25 May 2018

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Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin

25 May 2018

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Huntington disease and the huntingtin protein

25 May 2018

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Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease.

25 May 2018

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Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment

25 May 2018

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The role of PGC-1α in the pathogenesis of neurodegenerative disorders

25 May 2018

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Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench

25 May 2018

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Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease

25 May 2018

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Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

25 May 2018

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Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

25 May 2018

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25 May 2018

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25 May 2018

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Psychiatric and cognitive difficulties as indicators of juvenile huntington disease onset in 29 patients

25 May 2018

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25 May 2018

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NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1

25 May 2018

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RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice

25 May 2018

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25 May 2018

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The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies

25 May 2018

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25 May 2018

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Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons

25 May 2018

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Juvenile Huntington's disease: does a dosage-effect pathogenic mechanism differ from the classical adult disease?

25 May 2018

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White matter volume and cognitive dysfunction in early Huntington's disease

25 May 2018

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Huntingtin processing in pathogenesis of Huntington disease.

25 May 2018

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

25 May 2018

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How does the Huntington's disease mutation damage cells?

25 May 2018

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Differential modulation of BMP signaling promotes the elaboration of cerebral cortical GABAergic neurons or oligodendrocytes from a common sonic hedgehog-responsive ventral forebrain progenitor species

25 May 2018

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25 May 2018

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Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

25 May 2018

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25 May 2018

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Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

25 May 2018

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25 May 2018

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Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

25 May 2018

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Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

25 May 2018

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Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

25 May 2018

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Transient compartmental expression of a family of protein tyrosine phosphatases in the developing striatum

25 May 2018

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Huntington's disease. Their loss is our gain?

25 May 2018

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

25 May 2018

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Inactivation of the mouse Huntington's disease gene homolog Hdh

25 May 2018

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Huntington's disease in children. Neuropathologic study of four cases

25 May 2018

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Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease

25 May 2018

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Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleus

25 May 2018

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Cortical inhibitory deficits in premanifest and early Huntington's disease

25 May 2018

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Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex

15 August 2018

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MRI measures of corpus callosum iron and myelin in early Huntington's disease.

15 August 2018

1 reference

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Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease

15 August 2018

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Diffusion tensor imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits

15 August 2018

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Subclasses of oligodendrocytes populate the mouse hippocampus.

15 August 2018

1 reference

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Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity

15 August 2018

1 reference

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Morphometric analysis of oligodendrocytes in the adult mouse frontal cortex

15 August 2018

1 reference

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Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications

15 August 2018

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Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease.

15 August 2018

1 reference

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Wild-type huntingtin protects neurons from excitotoxicity

15 August 2018

1 reference

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Brain structure in preclinical Huntington's disease.

15 August 2018

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The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines

15 August 2018

1 reference

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Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation

15 August 2018

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The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102778

Quantitative neuropathological changes in presymptomatic Huntington's disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102778

Regional specificity of brain atrophy in Huntington's disease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102778

Juvenile Huntington disease: CT and MR features.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102778

Juvenile Huntington disease in an 18-month-old boy revealed by global developmental delay and reduced cerebellar volume

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102778

Neuronal birthdate underlies the development of striatal compartments

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27623015

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NBD.2016.09.006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623015%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623015%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

PubMed publication ID

27623015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623015%20AND%20SRC:MED&resulttype=core&format=json